PELP1表达与胃癌演进及预后相关性分析

doi:10.11904/j.issn.1002-3070.2022.01.006

实用肿瘤学杂志 ›› 2022, Vol. 36 ›› Issue (1): 31-36.doi: 10.11904/j.issn.1002-3070.2022.01.006

PELP1表达与胃癌演进及预后相关性分析

赵宝山¹, 梁冠盈², 许圣洁³, 乔慧⁴, 陈洪霞¹, 马莹¹, 鞠学萍⁵, 王麟¹

1.哈尔滨医科大学大庆校区基础医学院病理学教研室(大庆 163319);
2.哈尔滨医科大学附属肿瘤医院病理科;
3.宁波临床病理诊断中心;
4.大庆油田总医院消化内科;
5.大庆市第四医院病理科

收稿日期:2021-08-06 修回日期:2021-10-09 出版日期:2022-02-28 发布日期:2022-01-21
通讯作者: 王麟,E-mail:wangl_cmu@126.com
作者简介:赵宝山,男,(1984-),硕士,讲师,从事肿瘤侵袭病理机制的研究。
基金资助:
黑龙江省卫生健康委员会项目(编号:2017-174);黑龙江省高校科研基金(编号:JFXN2019010)

Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis

ZHAO Baoshan¹, LIANG Guanying², XU Shengjie³, QIAO Hui⁴, CHEN Hongxia¹, MA Ying¹, JU Xueping⁵, WANG Lin¹

1. Department of Pathology,College of Basic Medical Sciences,Harbin Medical University-Daqing,Daqing 163319,China;
2. Department of Pathology,Harbin Medical University Cancer Hospital;
3. Ningbo Clinicopathological Diagnosis Center;
4. Department of Gastroenterology,Daqing Oilfield General Hospital;
5. Department of Pathology,Fourth Hospital of Daqing

Received:2021-08-06 Revised:2021-10-09 Online:2022-02-28 Published:2022-01-21

摘要/Abstract

摘要： 目的探讨脯氨酸-谷氨酸-亮氨酸富集蛋白1(Proline,glutamate and leucine rich protein 1,PELP1)表达与胃癌演进及预后的关系及意义。方法采用免疫组化检测39例正常胃组织、48例低级别不典型增生胃组织、28例高级别不典型增生胃组织、77例胃癌组织中PELP1蛋白表达水平,观察胃癌不同演进阶段PELP1表达变化;分析胃癌患者PELP1表达水平与临床病理参数关系;通过在线癌症生存分析工具Kaplan-Meier Plotter分析胃癌PELP1表达与患者总生存期、首次进展前生存期和进展后生存期之间的关系。结果胃癌演进过程中,PELP1表达水平逐渐升高,差异具有统计学意义(P＜0.05);胃癌组织中PELP1表达与淋巴结转移、低肿瘤分化、高临床分期有关(P＜0.05);PELP1高表达组患者总生存期、首次进展前生存期和进展后生存期均显著低于PELP1低表达组患者(P＜0.05)。结论高表达PELP1参与胃癌演进并且提示患者预后不良。

关键词: 胃癌, 脯氨酸-谷氨酸-亮氨酸富集蛋白1, 免疫组织化学, 生存分析

Abstract: Objective The aim of this study was to investigate the relationship and significance of proline,glutamate and leucine rich protein 1(PELP1)in the progression and prognosis of gastric cancer.Methods Immunohistochemistry was used to detect the expression of PELP1 protein in 39 normal gastric tissues,48 low-grade atypical hyperplasia gastric tissues,28 high-grade atypical hyperplasia gastric tissues,and 77 gastric cancer tissues.The expression of PELP1 in different stages of gastric cancer was observed.The correlation between the level of PELP1 and clinicopathological parameters of gastric cancer was analyzed.Kaplan-Meier Plotter,an online cancer survival analysis tool,was used to analyze the relationship between PELP1 expression in gastric cancer and overall survival(OS),survival before first progression(FP)and post progression survival(PPS).Results The level of PELP1 increased gradually during the progression of gastric cancer,and the differences were significant(P＜ 0.05);The expression of PELP1 in gastric cancer was significantly correlated with lymph node metastasis,low tumor differentiation and high clinical stage(P＜ 0.05);The OS,FP and PPS of patients with high level of PELP1 were significantly shorter than those with low level of PELP1(P ＜ 0.05).Conclusion The high expression of PELP1 is involved in the progression of gastric cancer and suggests a poor prognosis for patients.

Key words: Gastric Cancer, Proline,glutamic and leucine rich protein 1, Immunohistochemistry, Survival analysis

中图分类号:

R735.2

赵宝山, 梁冠盈, 许圣洁, 乔慧, 陈洪霞, 马莹, 鞠学萍, 王麟. PELP1表达与胃癌演进及预后相关性分析[J]. 实用肿瘤学杂志, 2022, 36(1): 31-36.

ZHAO Baoshan, LIANG Guanying, XU Shengjie, QIAO Hui, CHEN Hongxia, MA Ying, JU Xueping, WANG Lin. Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis[J]. Journal of Practical Oncology, 2022, 36(1): 31-36.

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PELP1表达与胃癌演进及预后相关性分析

Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis

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