巨噬细胞/小胶质细胞在胶质瘤微环境中的研究进展

doi:10.11904/j.issn.1002-3070.2023.05.010

摘要/Abstract

摘要： 胶质瘤作为最常见的中枢神经系统肿瘤,经手术、放疗及化疗等综合方案治疗后,患者预后仍然欠佳。肿瘤的发生发展、侵袭和治疗抵抗等与肿瘤微环境中的免疫浸润细胞关系密切。巨噬细胞/小胶质细胞是胶质瘤微环境中主要的免疫浸润细胞,近年来对其研究取得了很大的进展,为胶质瘤的治疗提供了新的思路。本文对巨噬细胞/小胶质细胞在胶质瘤微环境中的研究进展进行综述。

关键词: 胶质瘤, 肿瘤微环境, 巨噬细胞/小胶质细胞

Abstract: Gliomas,as the most common central nervous system tumors,still have a poor prognosis for patients after comprehensive treatment with surgery,radiotherapy,and chemotherapy.The occurrence,development,invasion and treatment resistance of tumors are closely related to the immune infiltrating cells in the tumor microenvironment.Macrophages/microglia are the main immune-infiltrating cells in the microenvironment of gliomas,and significant progress has been made in their research in recent years,providing new ideas for the treatment of gliomas.This article reviews the research progress of macrophages/microglia in the microenvironment of glioma.

Key words: Glioma, Tumor microenvironment, Macrophages/microglia

中图分类号:

R739.41

罗汀繁, 孙鹏飞. 巨噬细胞/小胶质细胞在胶质瘤微环境中的研究进展[J]. 实用肿瘤学杂志, 2023, 37(5): 443-448.

LUO Tingfan, SUN Pengfei. Research progress of macrophages/microglia in the microenvironment of glioma[J]. Journal of Practical Oncology, 2023, 37(5): 443-448.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2023.05.010

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2023/V37/I5/443

参考文献

1 Molinaro AM,Taylor JW,Wiencke JK,et al.Genetic and molecular epidemiology of adult diffuse glioma[J].Nat Rev Neurol,2019,15(7):405-417.
2 Yang MF,Oh IY,Mahanty A,et al.Immunotherapy for glioblastoma:current state,challenges,and future perspectives[J].Cancers(Basel),2020,12(9):2334.
3 van Solinge TS,Nieland L,Chiocca EA,et al.Advances in local therapy for glioblastoma-taking the fight to the tumour[J].Nat Rev Neurol,2022,18(4):221-236.
4 徐洋,秦琪,赵红,等.肿瘤微环境异质性的研究进展[J].实用肿瘤学杂志,2017,31(3):258-261.
5 Hara T,Chanoch-Myers R,Mathewson ND,et al.Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma[J].Cancer Cell,2021,39(6):779-792.
6 Hambardzumyan D,Gutmann DH,Kettenmann H.The role of microglia and macrophages in glioma maintenance and progression[J].Nat Neurosci,2016,19(1):20-27.
7 Shapouri-Moghaddam A,Mohammadian S,Vazini H,et al.Macrophage plasticity,polarization,and function in health and disease[J].J Cell Physiol,2018,233(9):6425-6440.
8 Ginhoux F,Guilliams M.Tissue-resident macrophage ontogeny and homeostasis[J].Immunity,2016,44(3):439-449.
9 Pombo Antunes AR,Scheyltjens I,Lodi F,et al.Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization[J].Nat Neurosci,2021,24(4):595-610.
10 Takenaka MC,Gabriely G,Rothhammer V,et al.Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39[J].Nat Neurosci,2019,22(5):729-740.
11 Geraldo LH,Xu YL,Jacob L,et al.SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia[J].J Clin Invest,2021,131(16):e141083.
12 Wang QW,Sun LH,Zhang Y,et al.MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor-associated,macrophages-mediated immunosuppression in primary glioblastomas[J].J Immunother Cancer,2021,9(10):e002451.
13 Dong F,Qin XY,Wang BF,et al.ALKBH5 facilitates hypoxia-induced paraspeckle assembly and IL8 secretion to generate an immunosuppressive tumor microenvironment[J].Cancer Res,2021,81(23):5876-5888.
14 Gangoso E,Southgate B,Bradley L,et al.Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion[J].Cell,2021,184(9):2454-2470.
15 Murray PJ,Allen JE,Biswas SK,et al.Macrophage activation and polarization:nomenclature and experimental guidelines[J].Immunity,2014,41(1):14-20.
16 Grabowski MM,Sankey EW,Ryan KJ,et al.Immune suppression in gliomas[J].J Neurooncol,2021,151(1):3-12.
17 Propper DJ,Balkwill FR.Harnessing cytokines and chemokines for cancer therapy[J].Nat Rev Clin Oncol,2022,19(4):237-253.
18 De Boeck A,Ahn BY,D'Mello C,et al.Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression[J].Nat Commun,2020,11(1):4997.
19 Zhai K,Huang Z,Huang Q,et al.Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells[J].Nat Cancer,2021,2(11):1136-1151.
20 Guo Q,Shen S,Guan GF,et al.Cancer cell intrinsic TIM-3 induces glioblastoma progression[J].iScience,2022,25(11):105329.
21 Li ZW,Meng XQ,Wu PF,et al.Glioblastoma cell-derived lncRNA-containing exosomes induce microglia to produce complement C5,promoting chemotherapy resistance[J].Cancer Immunol Res,2021,9(12):1383-1399.
22 Li Z,Fu WJ,Chen XQ,et al.Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization[J].J Exp Clin Cancer Res,2022,41(1):74.
23 张培,曹守波,于雁.自噬介导的肿瘤相关巨噬细胞调控机制的研究进展[J].实用肿瘤学杂志,2018,32(2):130-134.
24 Fukushi A,Kim HD,Chang YC,et al.Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells[J].Int J Mol Sci,2022,23(17):10037.
25 Lu J,Xu ZY,Duan HB,et al.Tumor-associated macrophage interleukin-β promotes glycerol-3-phosphate dehydrogenase activation,glycolysis and tumorigenesis in glioma cells[J].Cancer Sci,2020,111(6):1979-1990.
26 Azambuja JH,Ludwig N,Yerneni SS,et al.Arginase-1+ exosomes from reprogrammed macrophages promote glioblastoma progression[J].Int J Mol Sci,2020,21(11):3990.
27 Zhang X,Chen L,Dang WQ,et al.CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling[J].Lab Invest,2020,100(4):619-629.
28 Yu-Ju Wu C,Chen CH,Lin CY,et al.CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2[J].Neuro Oncol,2020,22(2):253-266.
29 Andreucci E,Peppicelli S,Ruzzolini J,et al.Physicochemical aspects of the tumour microenvironment as drivers of vasculogenic mimicry[J].Cancer Metastasis Rev,2022,41(4):935-951.
30 Wei QX,Singh O,Ekinci C,et al.TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy[J].Acta Neuropathol Commun,2021,9(1):67.
31 Ni XG,Wu WC,Sun XQ,et al.Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma[J].Sci Adv,2022,8(27):eabl5165.
32 Blank A,Kremenetskaia I,Urbantat RM,et al.Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma[J].J Pathol,2021,253(2):160-173.
33 Dumas AA,Pomella N,Rosser G,et al.Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment[J].Embo J,2020,39(15):e103790.
34 Campesato LF,Budhu S,Tchaicha J,et al.Blockade of the AHR restricts a treg-macrophage suppressive axis induced by L-kynurenine[J].Nat Commun,2020,11(1):4011.
35 Kesarwani P,Kant S,Zhao Y,et al.Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis[J].Nat Commun,2023,14(1):1459.
36 Magri S,Musca B,Pinton L,et al.The immunosuppression pathway of tumor-associated macrophages is controlled by heme oxygenase-1 in glioblastoma patients[J].Int J Cancer,2022,151(12):2265-2277.
37 Ho WS,Mondal I,Xu BS,et al.PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages[J].J Clin Invest,2023,133(6):e162139.
38 Flores-Toro JA,Luo D,Gopinath A,et al.CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas[J].Proc Natl Acad Sci U S A,2020,117(2):1129-1138.
39 Moorman HR,Poschel D,Klement JD,et al.Osteopontin:a key regulator of tumor progression and immunomodulation[J].Cancers(Basel),2020,12(11):3379.
40 Wei J,Marisetty A,Schrand B,et al.Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target[J].J Clin Invest,2019,129(1):137-149.
41 Cui X,Ma C,Vasudevaraja V,et al.Dissecting the immunosuppressive tumor microenvironments in glioblastoma-on-a-chip for optimized PD-1 immunotherapy[J].Elife,2020,9:e52253.
42 Rao R,Han R,Ogurek S,et al.Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition[J].Neuro Oncol,2022,24(4):584-597.
43 Zhang L,Alizadeh D,Van Handel M,et al.Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice[J].Glia,2009,57(13):1458-1467.
44 Liu Y,Li X,Zhang Y,et al.An miR-340-5p-macrophage feedback loop modulates the progression and tumor microenvironment of glioblastoma multiforme[J].Oncogene,2019,38(49):7399-7415.
45 Peterson TE,Kirkpatrick ND,Huang Y,et al.Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages[J].Proc Natl Acad Sci USA,2016,113(16):4470-4475.
46 Zhang F,Parayath NN,Ene CI,et al.Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers[J].Nat Commun,2019,10(1):3974.
47 von Roemeling CA,Wang Y,Qie Y,et al.Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity[J].Nat Commun,2020,11(1):1508.
48 Jiang N,Xie BW,Xiao WW,et al.Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion[J].Nat Commun,2022,13(1):1511.
49 Chen Y,Yu Z,Tan X,et al.CAR-macrophage:a new immunotherapy candidate against solid tumors[J].Biomed Pharmacother,2021,139:111605.
50 Chen C,Jing W,Chen Y,et al.Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy[J].Sci Transl Med,2022,14(656):1128.

[1]	曹莹月, 庞露薏, 张键, 金时. 癌相关成纤维细胞在非小细胞肺癌进展中的作用[J]. 实用肿瘤学杂志, 2023, 37(4): 383-388.
[2]	刘欣欣, 马西元, 缪美琪, 王语晴, 陈晶. IL-6及其受体在乳腺癌治疗中的作用研究进展[J]. 实用肿瘤学杂志, 2023, 37(2): 149-154.
[3]	张淑敏, 张弓. ILC2s在肿瘤免疫调控中的研究进展[J]. 实用肿瘤学杂志, 2022, 36(6): 566-569.
[4]	李雄, 姜文凯, 郎泽昆, 芮少珍. 肿瘤相关中性粒细胞与胰腺癌关系的研究进展[J]. 实用肿瘤学杂志, 2022, 36(5): 458-462.
[5]	孙阜圣, 徐冶, 张永健, 娄阁. 卵巢癌类器官模型的研究进展和治疗新策略[J]. 实用肿瘤学杂志, 2022, 36(4): 346-350.
[6]	刘欣欣, 姚欣卉, 孙跃峰, 缪美琪, 陈晶. 乳腺癌微环境中趋化因子CCL20作用的研究进展[J]. 实用肿瘤学杂志, 2022, 36(3): 250-254.
[7]	刘雨, 俞星新, 耿志达, 陈政良, 惠鹏, 梁英健. 成纤维细胞在肝癌发生发展中的作用[J]. 实用肿瘤学杂志, 2022, 36(2): 167-172.
[8]	董丽娜, 梁田, 张献, 张广美. 卵巢癌对富脂大网膜的器官趋向性转移的研究进展[J]. 实用肿瘤学杂志, 2022, 36(1): 54-58.
[9]	牟冠男, 马强. NK细胞极化在子宫内膜癌中的作用[J]. 实用肿瘤学杂志, 2021, 35(6): 534-537.
[10]	隆园辉, 陈雪松. 心理应激对肿瘤微环境中免疫细胞影响的研究进展[J]. 实用肿瘤学杂志, 2021, 35(5): 436-440.
[11]	贾晓琼, 孙秋颖, 刘晓宇, 信涛. miR-182靶向调控PI3K/AKT/FOXO3a信号通路对胶质瘤干细胞生物学行为的影响及其机制研究[J]. 实用肿瘤学杂志, 2021, 35(2): 103-109.
[12]	张遥, 范丹. 长链非编码RNA PSMA3-AS1在人胶质瘤细胞中的表达及作用研究[J]. 实用肿瘤学杂志, 2020, 34(3): 214-219.
[13]	张巍, 姜晓东, 迟大鹏. WNT4在脑胶质瘤中甲基化下调及抑制恶性胶质瘤细胞增殖的研究[J]. 实用肿瘤学杂志, 2020, 34(2): 156-162.
[14]	张慧婷, 娄阁. 卵巢癌肿瘤微环境的三维细胞培养模型研究进展[J]. 实用肿瘤学杂志, 2019, 33(6): 557-560.
[15]	李悦, 徐可, 韩增祥, 孙敏, 樊国华综述, 张勇审校. 结肠癌中肿瘤相关巨噬细胞的作用及靶向治疗的研究进展[J]. 实用肿瘤学杂志, 2018, 32(5): 450-454.