PRACTICAL ONCOLOGY JOURNAL ›› 2016, Vol. 30 ›› Issue (4): 365-369.doi: 10.11904/j.issn.1002-3070.2016.04.014

• Review • Previous Articles     Next Articles

Research progresses of Renin-angiotensin system receptors in breast cancer

WANG Ting,CHEN Xuesong   

  1. Department of Oncology,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China
  • Received:2016-04-14 Online:2016-08-10 Published:2016-08-19

Abstract:

Recent studies had demonstrated that Renin-angiotensin system(RAS)plays an important role not only in the cardiovascular system,but also in the occurrence and development of breast cancer.Associated with RAS receptor,Angiotensin Ⅱ(Ang Ⅱ)and Angiotensin 1-7(Ang1-7)which are the major molecules of the RAS,respectively,promote or inhibit the occurrence and development of tumor.In this review,we summarize the current knowledge of the RAS in breast cancer,and discuss the potential application of RAS related receptors targeted drugs in the clinical treatment of breast cancer.

Key words: Renin-angiotensin system, RAS receptor, Breast cancer

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