TACE后残余肝癌细胞β-catenin和p28GANK的表达及意义的研究

doi:10.11904/j.issn.1002-3070.2016.05.009

Abstract

Abstract: Objective To investigate the expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma(HCC)cells after transcatheter arterial chemoembolization(TACE).Methods We collected forty-five cases of surgical specimens of hepatocellular carcinoma after TACE(TACE group)and thirty cases of surgery without any treatment(pure surgery group).The expression of β-catenin and p28GANK were detected by using immunohistochemical SP method and compared between the two groups.Results The positive expression of β-catenin and p28GANK in TACE group were 77.78% and 75.56% respectively,which were significantly higher than those in pure surgery group(46.67% and 53.33% respectively,P＜0.05).In the residual hepatocellular carcinoma cells of TACE group,the positive expression of β-catenin showed correlation with the positive expression of p28GANK(Φ=0.318,P=0.033).The high expression of β-catenin and p28GANK were closely related to portal vein thrombosis and distant metastasis(P＜0.05).Conclusion The expression of β-catenin and p28GANK in the residual hepatocellular carcinoma cells were increased significantly after TACE.The high expression of β-catenin and p28GANK were closely related to portal vein thrombosis and distant metastasis.The high expression of β-catenin and p28GANK may be one of the reasons of hepatocellular carcinoma invasiveness and metastasis.

Key words: Hepatocellular carcinoma, Transcatheter arterial chemoembolization, β-catenin, p28GANK

CLC Number:

R735.7

LI Shijie, YANG Yi, TIAN Yulong, HOU Jiye, LIU Ruibao. The expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma cells after transcatheter arterial chemoembolization[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 430-435.

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The expression and significance of β-catenin and p28GANK in residual hepatocellular carcinoma cells after transcatheter arterial chemoembolization

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