CD4+CD25+Foxp3+Treg细胞调控肿瘤免疫抑制微环境的研究进展

doi:10.11904/j.issn.1002-3070.2016.06.016

Abstract

Abstract: CD4⁺CD25⁺Foxp3⁺regulatory T cells(Tregs)are essential for tumor immunosuppressive microenvironment and secrete some inhibitory cytokines IL-10,IL-35,TGF-β1 and FGL2 which are key mediators of Treg immunosuppressive function.Tregs have been shown to be important contributors to the tumor escape immunosurveillance and play a critical role in the induction of suppression to CD4⁺T,CD8⁺T and NK cell,and suppression of specific anti-tumor immunity.Further research of the role of Tregs in tumor immunosuppressive microenvironment is important to understand malignant tumor pathogenetic and immunological therapeutics.In addition,Tregs and inhibitory cytokines become more critical for clinical applications,prognosis evaluation and therapies.

Key words: Regulatory T cell, Tumor escape, Immunosuppression microenvironment

CLC Number:

R730.2

LIU Jiaqi,LIU Yaohua,CHEN Xin,ZHAO Shiguang. Research progress of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in tumor immunosuppressive microenvironment[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 555-559.

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Research progress of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in tumor immunosuppressive microenvironment

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Research progress of CD4+CD25+Foxp3+ regulatory T cells in tumor immunosuppressive microenvironment

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Research progress of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in tumor immunosuppressive microenvironment