PRACTICAL ONCOLOGY JOURNAL ›› 2016, Vol. 30 ›› Issue (6): 551-554.doi: 10.11904/j.issn.1002-3070.2016.06.015

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The research progresses in USP22 in malignant tumors

WANG Jijun,HE Yan   

  1. Department of Pathology,Harbin Medical University,Harbin 150081,China
  • Received:2016-07-20 Online:2016-12-31 Published:2016-12-27

Abstract: Deubiquitylases remove ubiquitin moieties from different substrates to regulate protein activity and cell homeostasis.Since this posttranslational modification plays a role in several different cellular functions,its deregulation has been associated with different pathologies.Aberrant expression of Ubiquitin-Specific Peptidase 22(USP22)has been associated with poor cancer prognosis.This article reviews the research status of USP22.

Key words: Malignant tumor, Overexpression, USP22

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