长链非编码RNA EPB41L4A-AS2对乳腺癌的预后研究

doi:10.11904/j.issn.1002-3070.2017.03.003

Abstract

Abstract: Objective The relationship between the clinicopathological features and the prognosis of breast cancer patients was evaluated by the expression of EPB41L4A-AS2 in breast cancer tissues.Methods The relationship between the expression of EPB41L4A-AS2 and the clinical features of breast cancer was evaluated by using the genome meta analysis,TCGA and Gene Expression Library(GEO)datasets.The correlation between EPB41L4A-AS2 and apoptotic pathway was verified by Western blotting.Results The results from Meta-analysis,TCGA and GEO datasets showed that EPB41L4A-AS2 was low in breast cancer tissues and was positively correlated with poor clinical and pathological features.EPB41L4A-AS2 was confirmed an association with the classical apoptosis pathway in breast cancer cell lines.In the meta-analysis of GEO,we found the high expression of EPB41L4A-AS2 with good prognosis.Conclusion EPB41L4A-AS2 inhibits tumor formation and has a high value in clinical prognosis of breast cancer.

Key words: Long non-coding RNA, Breast cancer, EPB41L4A-AS2

CLC Number:

R737.3

CHEN Qianlin,PANG Da. Long noncoding RNA EPB41L4A-AS2 associated with the prognosis of tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 205-210.

References

1 Risueno A,Fontanillo C,Dinger ME,et al.GATExplorer:genomic and transcriptomic explorer;mapping expression probes to gene loci,transcripts,exons and ncRNAs[J].BMC Bioinformatics,2010,11(221):1-12.
2 Huang da W,Sherman BT,Lempicki RA.Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources[J].Nat Protoc,2009,4(4):44-57.
3 Zhang B,Horvath S.A general framework for weighted gene co-expression network analysis[J].Stat Appl Genet Mol Biol,2005,4(1):1-43.
4 Wei Y,Niu B.Role of MALAT1 as a Prognostic factor for survival in various cancers:A systematic review of the literature with meta-analysis[J].Disease Markers,2015,1(6):1-9.
5 Yang L,Bai HS,Deng Y,et al.High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion[J].Eur Rev Med Pharmacol Sci,2015,19(17):3187-3193.
6 Zhang J,Zhang B,Wang T,et al.LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer:evidence from a meta-analysis[J].Int J Clin Exp Med,2015,8(4):5499-5505.
7 Loewen G,Jayawickramarajah J,Zhuo Y,et al.Functions of LncRNA HOTAIR in lung cancer[J].J Hematol Oncol,2014,7(90):1-10.
8 Gokmen-Polar Y,Vladislav IT,Neelamraju Y,et al.Prognostic impact of HOTAIR expression is restricted to ER-negative breast cancers[J].Sci Rep,2015,5(8765):1-5.
9 Gu Y,Chen T,Li G,et al.LncRNAs:emerging biomarkers in gastric cancer[J].Future Oncol,2015,11(7):1-15.
10 Wang S,Wang Z.Prognostic value of long noncoding RNA HOTAIR in digestive system malignancies[J].J Gastroenterol Hepatol,2015,7(30):1123-1133.
11 Yu X,Li Z.Long non-coding RNA HOTAIR:A novel oncogene(Review)[J].Mol Med Rep,2015,4(12):5611-5618.
12 Zhao W,Dong S,Duan B,et al.HOTAIR is a predictive and prognostic biomarker for patients with advanced gastric adenocarcinoma receiving fluorouracil and platinum combination chemotherapy[J].Am J Transl Res,2015,7(7):1295-1302.

[1]	WANG Xiaoya,XIAO Bin,LIAO Yang,TANG Rongzhi,SUN Zhaohui,LI Linhai. Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 206-210.
[2]	LI Shuo,ZHANG Nannan,LI Liangliang,LONG Zhiping,YIN Huihui,ZHAO Yashuang,WANG Fan. Relationship between PDE4C gene methylation in peripheral blood leukocytes,interaction of environmental factors and pathogenesis of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 233-238.
[3]	CHEN Yanbo, KONG Dejia, ZHANG Jinfeng, MA Zhigang. Correlation between CYP2D6 gene polymorphism and tamoxifen metabolism in breast cancer patients [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 110-114.
[4]	SUN Jianghong, HAO Mingzhu, JIANG Dan, GUO Fei, LI Xiaomei. FFDM differential diagnosis of mastitis,benign hyperplasia and breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 139-141.
[5]	MA Zhijie, WANG Fan, ZHAO Yashuang. Analysis of life quality and influencing factors in breast cancer patients with chemotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 149-154.
[6]	MA Zhingying, SHANG Naijian, CAI Miaotian, SHEN Yang, JIANG Zhiyun. Correlation between HER-2 receptor of progesterone and estrogen receptor-positive breast cancer and mammography imaging & clinicopathological features [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 47-51.
[7]	HE Xu, YE shangmian, DONG dandan, LI Ke. The expression of HLA-G in breast cancer and its significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 410-414.
[8]	LIN Rongjie, YIN Hang, ZHOU Yunfeng. Effect of ON123300 on ER+ human breast cancer MCF-7 cells and its mechanism [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 193-197.
[9]	XU Wenpin, JIAO Kun, ZHANG Wei. Research progress of Long non-coding RNAs in oral squamous cell carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 258-262.
[10]	LI Lin, LI Zhigao. The relationship between metformin and different molecular subtypes of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 267-270.
[11]	YANG Zhao, ZHAO Shiguang. Long non-coding RNA CASC2 inhibits progression and development of tumor [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 179-183.
[12]	ZHANG Zhongmin, PANG Da. Research progress of long non-coding RNA regulates cancer cell signaling pathways [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 184-188.
[13]	ZHENG Wei, XU Shouping, PANG Da. Expression,prognosis and function of long chain non-coding RNA-Linc00152 in breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 7-13.
[14]	YIN Yulian, ZHANG Weihong, ZHOU Yue, YE Meina, CHEN Hongfeng. Correlation between single nucleotide polymorphisms of ERα gene and bone loss associated with aromatase inhibitors in postmenopausal women with breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 14-18.
[15]	LI Yujiao, SHANG Naijian. Research progress of imaging evaluation of neoadjuvant chemotherapy in breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 63-67.

Long noncoding RNA EPB41L4A-AS2 associated with the prognosis of tumors

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments