Abstract: Objective The objective of this study was to observe the short-term and long-term curative effects of minimally invasive surgical treatment combined with chemotherapy of localized nasopharyngeal carcinoma in patients,and to clarify the necessity of combination therapy in patients with nasopharyngeal carcinoma.Methods Sixty-two patients with nasopharyngeal carcinoma were enrolled in our hospital from March 2011 to September 2011.The patients were divided into the observation and control groups by random number table method.The patients in observation group were given the application of minimally invasive surgery with postoperative combined chemotherapy with cisplatin and 5-fluorouracil after nasal endoscopic resection.The patients in the control group were given single application of minimally invasive surgical treatment of nasal endoscopic resection.The patients in two groups were observed the efficiency,survival rate and postoperative quality of life after surgery for 1 year or 5 years.Results The effective rate was 83.87% and 100% for the survival rate in the observation group after surgery for 1 year;the effective rate was 58.06% and 87.10% for the survival rate in the control group.There was significant different between the observation and control groups(P＜0.05).The survival and survival rates were significantly higher than those in the control group after surgery for 5 years(P＜0.05).After surgery 1 year,the scores of the patients in the observation group were significantly higher than those in the control group(P＜0.05).Conclusion The combination of cisplatin and 5-fluorouracil in the treatment of minimally invasive endoscopic nasopharyngeal resection combined with postoperative chemotherapy can significantly improve the short-and long-term survival rates,long-term effective rate,and quality of life in tumor patients after surgery.This is suitable for clinical application.

Key words: Localized nasopharyngeal carcinoma, Minimally invasive surgery, Minimally invasive surgery, Drug, Curative effect