NF-κB对大肠癌发生发展的影响及其相关治疗的研究现状

doi:10.11904/j.issn.1002-3070.2017.01.009

Abstract

Abstract: In eukaryotic cells,NF-κB transcription factor family regulates many processes like cell survival,growth,and apoptosis.It participates in the development of a variety of diseases,including inflammatory,immune disease,and cancer.As an inflammatory factor,NF-κB mediates the transformation of chronic colitis to cancer during the course of colorectal cancer.Furthermore,it could inhibit cell apoptosis through regulating cell cycles,which promotes the development of colorectal cancer and mediates the multidrug resistance of the tumor cells.Therefore,targeting NF-κB,a large number of preparations involved both Chinese and western medicine has been researched.The further research and the use of them may be an effective method to cure the colorectal cancer in clinical work.

Key words: NF-KappaB, Colitis, Colorectal neoplasm, Drug resistance

CLC Number:

R735.3

DUAN Peiwen, ZHAO Miaomiao, WANG Songpo. The recent advances in the research of NF-κB in the development and relevant treatment of the colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 43-47.

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The recent advances in the research of NF-κB in the development and relevant treatment of the colorectal cancer

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