GOLPH2在恶性肿瘤中作用及机制的研究进展

doi:10.11904/j.issn.1002-3070.2017.05.014

Abstract

Abstract: The current detection of serum tumor markers is still considered to be one of convenient and effective means for early diagnosis of tumor and monitoring tumor progression.Golgi phosphoprotein 2(GOLPH2)is a type II transmembrane protein presenting in the Golgi apparatus.In recent years,many studies have suggested that GOLPH2 is one of the most promising early serum markers for early diagnosis of tumor.In addition,many studies have beer shown that GOLPH2 is related to prognosis of lung cancer,gastric cancer,prostate cancer and other cancer-related prognosis involved in immune regulation,intracellular signal factor activation and degradation and promote epithelial-mesenchymal transition(EMT).Through these mechanisms to promote tumor progression and metastasis,GOLPH2 reduces the disease-free survival(DFS)and overall survival(OS).In this paper,we review the role of GOLPH2 in the progress and a variety of malignant tumors.

Key words: GOLPH2, Tumor, Serum markers, Metastasis

CLC Number:

FANG Xinghua, SONG Ying. Research advances in the role of GOLPH2 in malignant tumor and its mechanism[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 458-462.

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Research advances in the role of GOLPH2 in malignant tumor and its mechanism

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