乳腺癌脑转移的信号通路和分子机制的研究进展

doi:10.11904/j.issn.1002-3070.2017.05.016

Abstract

Abstract: Breast cancer is one of the highest incidence of cancer in women,most frequent sites of metastasis are the lung,bone,liver,and central nervous system.The incidence of central nervous system metastasis is about 15%.At present,there are Wnt and Notch pathways,EGFR and PTEN pathways,which may be related to the brain metastases in breast cancer.There may be related to VEGF and Stat3,tubulin and TOP2A,BNC1,GALNT9,CCDC8,HER2,HER3,MMP,FBPS,sarcosine and other factors.This paper summarizes the signaling pathways and molecular mechanisms that may lead to brain metastases in breast cancer,and we hope to provide new ideas for targeted therapy of brain metastases in breast cancer.

Key words: Breast cancer, Brain metastases, Mechanisms

CLC Number:

R737.9

JIN Tuan, ZHANG Qingyuan. Research propress in signaling pathways and molecular mechanisms of brain metastases in breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 468-471.

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Research propress in signaling pathways and molecular mechanisms of brain metastases in breast cancer

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