Abstract: Orphan nuclear receptors(ONRs)refer to nuclear receptors without ligands or unknown ligands.It has been found to an important regulatory role in many key physiological processes,resulting from the control of these receptors.But signal disorders often cause many diseases including cancer.Prostate cancer is one of the most common types of malignant tumors in the urogenital system.High morbidity,recurrence rate and mortality are synonymous.Although the early prognosis is good,the quality of life and prognosis are still poor in patients with advanced disease.As a hotspot in translational medicine research,good progress has been made in the diagnosis and treatment of advanced prostate cancer in recent years.This article reviews the research progress of ONRs in the mechanism and clinical relevance of prostate cancer,and provides a theoretical basis for the occurrence,development,invasion,metastasis and treatment of prostate cancer.

Key words: Orphan nuclear receptor, Nuclear receptor, Prostate cancer, Gene transcription expression