1 Yu M,Liu J,Li L,et al.Pharmacokinetic parameters of three active ingredients hederacoside C,hederacoside D,and α-hederin in Hedera helix in rats[J].J Sep Sci,2016,39(17):3292-3301.
2 Saadat S,Mohammadi M,Fallahi M,et al.The protective effect of α-hederin,the active constituent of Nigella sativa,on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs[J].J Physiol Sci,2015,65(3):285-292.
3 Prescott TA,Rigby LP,Veitch NC,et al.The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action[J].Phytochemistry,2014,101:116-120.
4 Swamy SMK,Huat BTK.Intracellular glutathione depletion and reactive oxygen species generation are important in α-hederin-induced apoptosis of P388 cells[J].Mol Cell Biochem,2003,245(1/2):127-139.
5 刘强.中药白头翁提取的新活性分子白头翁皂苷甲(BD)抗肿瘤作用的研究[D].苏州:苏州大学,2012.
6 Rooney S,Ryan MF.Effects of alpha-hederin and thymoquinone,constituents of Nigella sativa,on human cancer cell lines[J].Anticancer Res,2005,25(3):2199-2204.
7 Rooney S,Ryan MF.Modes of action of alpha-hederin and thymoquinone,active constituents of Nigella sativa,against HEp-2 cancer cells[J].Anticancer Res,2005,25(6):4255-4259.
8 王国娟,余文燕,郭红飞,等.α-常春藤皂苷抗结肠癌增殖作用研究[J].中药药理与临床,2017,33(4):43-47.
9 Eid AM,Elmarzugi NA,Abu ALM,et al.A review on the cosmeceutical and external applications of nigella sativa[J].J Trop Med,2017,2017:7092514.
10 张铁,彭翠平,王永林,等.α-常春藤皂苷抗肿瘤作用机制研究[J].中药新药与临床药理,2015,26(2):175-179.
11 张步鑫,赵献敏,成琼,等.α-常春藤皂苷对黑色素瘤B16细胞增殖和凋亡的影响及机制[J].中国实验方剂学杂志,2018,24(12):81-85.
12 Wang HY,Wu B,Wang HT,et al.Alpha-hederin induces the apoptosis of oral cancer SCC-25 cells by regulating PI3K/Akt/mTOR signaling pathway[J].Electron J Biotechn,2019,38:27-31.
13 Cheng L,Xia TS,Wang YF,et al.The anticancer effect and mechanism of α-hederin on breast cancer cells[J].Int J Oncol,2014,45(2):757-763.
14 李娇,马静静,胡雪,等.α-常春藤皂苷通过活性氧-线粒体途径促进食管癌细胞凋亡的研究[J].疑难病杂志,2018,17(9):932-935.
15 Li J,Wu DD,Zhang JX,et al.Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells[J].World J Gastroenterol,2018,24(17):1901-1910.
16 Lorent JH,Léonard C,Abouzi M,et al.α-Hederin induces apoptosis,membrane permeabilization and morphologic changes in two cancer cell lines through a cholesterol-dependent mechanism[J].Planta Med,2016,82(18):1532-1539.
17 Wojciechowski K,Orczyk M,Gutberlet T,et al.Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers[J].Biochim Biophys Acta,2015,1858(2):363-373.
18 Chwalek M,Lalun N,Bobichon H,et al.Structure-activity relationships of some hederagenin diglycosides:Haemolysis,cytotoxicity and apoptosis induction[J].Biochim Biophys Acta,2006,1760(9):1418-1427.
19 雷铭道,郑丽丽,张玲,等.α-常春藤皂苷一氧化氮供体衍生物的合成及其抗肿瘤活性研究[J].现代药物与临床,2019,34(1):1-4.
20 Bun SS,Elias R,Baghdikian B,et al.Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells[J].Phytother Res,2008,22(10):1299-1302.
21 Zhan Y,Wang K,Li Q,et al.The novel autophagy inhibitor alpha-hederin promoted paclitaxel cytotoxicity by increasing reactive oxygen species accumulation in non-small cell lung cancer cells[J].Int J Mol Sci,2018,19(10):3221.
22 Sun J,Feng Y,Wang Y,et al.α-Hederin induces autophagic cell death in colorectal cancer cellsthrough reactive oxygen species dependent AMPK/mTOR signaling pathway activation[J].Int J Oncol,2019,54(5):1601-1612.
23 Zhu R,Zhang CG,Liu Y,et al.CD147 monoclonal antibody mediated by chitosan nanoparticles loaded with α-hederin enhances antineoplastic activity and cellular uptake in liver cancer cells[J].Sci Rep,2015,5:17904.
24 Nicol A,Kwok RTK,Chen C,et al.Ultrafast delivery of aggregation-induced emission nanoparticles and pure organic phosphorescent nanocrystals by saponin encapsulation[J].J Am Chem Soc,2017,139(41):14792-14799.
25 Sun J,Liu T,Xu J.Improving the anticancer activity of α-hederin by physically encapsulating it with targeted micelles assembled from amphiphilic block copolymers[J].J Drug Deliv Sci Technol,2016,35:252-259. |
