PRACTICAL ONCOLOGY JOURNAL ›› 2015, Vol. 29 ›› Issue (1): 65-68.doi: 10.11904/j.issn.1002-3070.2015.01.014

• Review • Previous Articles     Next Articles

Research progress of transferrin and transferrin receptor on anti-tumor effect

CHEN Yueqi1,LIU Yimin2,ZHANG Dinglin2   

  1. 1.The Third Military Medical University Company 15,Chongqing 400038,China;
    2.Department of Chemistry,College of Pharmacy
  • Received:2014-06-03 Online:2015-02-28 Published:2015-03-06

Abstract: The transferrrin(Tf)and the transferrin receptor(TfR)are effective anti tumor agents which exist widely in human body.The Tf takes an important role in iron metabolism,while the TfR disturbs iron metabolism and controls the iron absorbing.The compound of Tf and TfR can induce tumor cells apoptosis.Therefore,the combination of Tf and TfR can inhibit tumor growth efficiently.In addition,it is also good for anti tumor indirectly by taking Tf/TfR as target and using artemisinin.This article will review and summarize the anti tumor effect of transferrin and transferrin receptor.

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