PRACTICAL ONCOLOGY JOURNAL ›› 2013, Vol. 27 ›› Issue (1): 1-7.doi: 10.3969/j.issn.1002-3070.2013.01.001

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Phycocyanine improves of the killing function of CBDC-CIK to liver cancer

ZHU Bisheng, ZENG Bohang, HOU Kailian, CHEN Jingqi   

  1. Department of Medical Oncology, The Secend Affiliated Hospital, Guangzhou Medical College, Guangzhou 510260, China
  • Received:2012-12-05 Online:2013-02-28 Published:2013-03-07

Abstract: Objective To investigate the phycocyanine influenced CBDC activating CIK to kill liver cancer.Methods The flow cytometry was used to detect the phenotype of CBDC induced by phycocyanine.The MTT was used to detect the killing function of CBDC-CIK to BEL-7402 liver cancer.Results Phycocyanine promoted CBDC maturation by inducing CD86 and CD83 expressions.When the effector-target ratio of CBDC-CIK to BEL-7402 was 80∶1, phycocyanine of 100μg/mL improved of killing BEL-7402 function of CBDC.Conclusion Phycocyanine improves the CBDC-CIK killing liver cancer function through inducing CBDC maturation.

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