HER2阳性乳腺癌治疗的研究进展

doi:10.11904/j.issn.1002-3070.2020.01.014

Abstract

Abstract: Human epithelial growth factor receptor 2(HER2)-positive breast cancer has been attracting attention because of its high invasiveness and poor prognosis.With the application of trastuzumab,the prognosis of patients with early HER2-positive breast cancer has been significantly improved.Because of its resistance and adverse reaction,the addition of new anti-HER2 drugs to standard treatment has become a new research project.These drugs include pertuzumab,antibody drug conjugate trastuzumab-emtansine(T-DM1)and various small molecule inhibitors(lapatinib,neratinib and pyrrolidone).At the same time,studies on PD1 and PD-L1 inhibitors such as pabolizumab in HER2-positive breast cancer are underway,some basic studies and case reports have confirmed its efficacy and safety.This article aims to provide an overview of current treatment options for HER2-positive breast cancer and the latest evidence for the treatment of HER2-positive breast cancer.

Key words: HER2, Breast cancer, Targeted therapy, Progression

CLC Number:

R730.5

LI Guozheng, PANG Da. Progression in the treatment of HER2-positive breast cancer[J]. Journal of Practical Oncology, 2020, 34(1): 74-78.

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Progression in the treatment of HER2-positive breast cancer

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