分化拮抗非蛋白质编码RNA(DANCR)在常见恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2020.01.013

Abstract

Abstract: According to GLOBOCAN 2018,lung cancer,breast cancer,colorectal cancer,gastric cancer and liver cancer account for about 43% of new global malignant tumors in 2018.A growing number of studies have shown that differentially antagonizing non-protein-encoding RNA(lncRNA-DANCR)is abnormally expressed in a variety of human cancers,and its aberrant expression promotes tumor progression by improving cancer cell proliferation and invasion.At the same time,the expression level of DANCR is significantly correlated with the histological grade of tumor and the prognosis of patient,making DANCR as a potential biomarker for a variety of cancers.This paper systematically reviews the research progress of lncRNA DANCR in common malignant tumors such as lung cancer,breast cancer,colorectal cancer,gastric cancer and liver cancer,in order to explain the molecular mechanisms and clinical significance of lncRNA DANCR in malignant tumors.

Key words: Long non-coding RNA, DANCR, Tumor, Molecular markers, Research progress

CLC Number:

GUO Yongdong, JIN Jing, LI Limin, HE Yutong. Progress in differentiation of non-protein-encoding RNA(DANCR)in common malignant tumors[J]. Journal of Practical Oncology, 2020, 34(1): 69-73.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.01.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I1/69

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Progress in differentiation of non-protein-encoding RNA(DANCR)in common malignant tumors

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