Abstract: Pancreaticoduodenectomy(PD)is the standard procedure for treatment of malignant tumors,precancerous lesions and some benign diseases around the ampulla.PD surgery has a wide range of resection,more anastomoses and more complications.In recent years,the mortality rate of PD surgery has dropped from more than the initial 50% to less than 5%,and the incidence of surgical complications has also decreased significantly.The main complications after PD are pancreatic fistula,bleeding,abdominal infection,biliary fistula,chyle,and postoperative gastric emptying disorder.Among them,pancreatic fistula is the main cause of early death after PD.This paper reviews the systemic factors,local factors and surgical related factors of pancreatic fistula after PD,and provides clinical operability for reducing the incidence after PD.

Key words: Pancreaticoduodenectomy, Pancreatic fistula, Risk factors