SPDEF与恶性肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2020.02.018

Abstract

Abstract: SAM pointed domain cintaining Ets transcription factor(SPDEF)is a member of the Ets transcription factor family.SPDEF is also known as prostate-derived Ets factor(PDEF).It was originally found in prostate cancer and plays an important role in the progression of prostate cancer,acting as a prostate-specific antigen(PSA)promoter for a non-androgen-dependent transcriptional activator.Current many studies have found that SPDEF plays a role in inhibiting tumors or promoting tumors in different tissues such as prostate cancer,breast cancer and lung cancer,but the specific mechanism has not been fully elucidated.This article mainly introduces the structure of SPDEF and the regulatory mechanism of SPDEF in different tumors.The important role of SPDEF in tumors is expected to provide new ideas for the prevention and treatment of related tumors.

Key words: SPDEF, Malignant tumor, Regulatory mechanism

CLC Number:

R730.2

LIN Yuhua, NI Zhenhua, SUN Yipeng, BI Junjie, WANG Xiongbiao. Research progress on the relationship between SPDEF and malignant tumors[J]. Journal of Practical Oncology, 2020, 34(2): 185-188.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.02.018

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I2/185

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Research progress on the relationship between SPDEF and malignant tumors

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