Abstract: Objective The aim of this study was to investigate the diagnostic value of ultrasound BI-RADS combined detection with serum CA15-3 and CEA in breast tumors. Methods A total of 111 patients with breast tumors from June 2019 to December 2019 were selected.The pathological results were used as the gold standard to analyze the sensitivity and accuracy of ultrasound BI-RADS,serum CA15-3 and CEA in the diaganosis of breast tumor. Results Pathological results showed 43 cases of benign lesions and 68 cases of breast cancer.Compared with patients with benign lesions,the increase in serum CA15-3 and CEA in breast cancer patients was statistically different.There was also a positive correlation between the increase of CA15-3 and CEA with breast cancer.By combining ultrasound BI-RADS with serum CA15-3 and CEA,the sensitivity for breast cancer diagnosis reached 73.5%,the accuracy increased to 83.8%,and the AUC of the ROC curve was increased to 0.957,which was higher than the results when they were used alone. Conclusion The combined detection of ultrasound BI-RADS,serum CA15-3 and CEA is an effective method to improve the sensitivity and accuracy of breast tumor diagnosis.

Key words: Breast cancer, Ultrasound examination, Carbohydrate antigen 15-3, Carcinoembryonic antigen