PRACTICAL ONCOLOGY JOURNAL ›› 2009, Vol. 23 ›› Issue (6): 501-504.doi: 10.3969/j.issn.1002-3070.2009.06.001

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The prognostic significance of breast cancer resistance protein expression in primary breast carcinoma

WNAG Shubin1, LIU Yajie1, SUN Yuping1, CHEN Yixin1, XU Min1, SUI Guangjie2, YANG Chunzheng3   

  1. 1.The Second Affiliated Hospital of Jinan University, Shenzhen People′s Hospital, Shenzhen 518020;
    2.The Affiliated Tumor Hospital of Harbin Medical University;
    3.Chinese Academy of Medical Sciences Institute of Hematology, Blood Disease Hospital
  • Received:2009-11-25 Online:2009-12-25 Published:2012-02-21

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Abstract: Objective Intrinsic and/or acquired resistance was the major obstacle to overcome in the treatment of patients with breast cancer.The aim of the present study was to investigate the relationship between the expression of breast cancer resistance protein(BCRP)with the clinicopathologic characteristics and the prognosis in primary breast cancer patients.Methods Expression of BCRP in 47 breast cancer patients was determined by immunohistochemistry on formalin-fixed, paraffin-embedded tumor section.Results (1)BCRP expression was observed in 26 of 47(55.3%).(2)No relation can be established between expression of BCRP and other clinicopathologic parameters.(3)Kaplan-Meier analyses revealed that BCRP expression only associated with disease-free survival(DFS)and didn′t with overall survival(OS).(4)In one-factor Cox analysis, tumor size and BCRP-positive staining was associated with DFS(P＜0.05).In addition, tumor size also associated with OS(P＜0.05).In multivariate Cox regression analysis, BCRP expression only associated with DFS.Lymph node metastasis was independent prognostic factor for DFS and OS(P＜0.05).Conclusions Our Results suggested that BCRP is frequently expression in primary breast cancer, but BCRP is not a poor prognostic factor in patients with breast cancer.

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