PRACTICAL ONCOLOGY JOURNAL ›› 2009, Vol. 23 ›› Issue (6): 505-508.doi: 10.3969/j.issn.1002-3070.2009.06.002

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Expression of inducible costimulator and variance of T cell subpopulations in patients with gastric cancer

LIU Yang1, WU Yan1, ZHAO Guohua2   

  1. 1.Basic Department, NeiMengGu Medical College, Huhehaote 010059;
    2.Department of Gastric Surgery, Liaoning Provincial Tumor Hospital
  • Received:2009-08-25 Online:2009-12-25 Published:2012-02-21

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Abstract: Objective To investigate the role of expression of T cell costimulatory molecule ICOS and variance of T cell subpopulations in the development and prognosis of gastric cancer.Methods The peripheral blood lymphocytes were tested for T cell subpopulations and T cell costimulatory molecule ICOS by flow cytometry in 38 patients with gastric cancer and 21 healthy peoples as control group.Results Compared gastric cancer group with control group:expressions of T cell costimulatory molecule ICOS were(25.80±10.56)vs(0.82±0.98)%, P＜0.01;expression percentage of total T cell(CD3+)were(53.61±13.84)vs(72.07±7.83)%, P＜0.01;expression percentage of CD4+T cell(CD4+CD3+)were(29.84±9.71)vs(38.79±5.08)%, P＜0.01;expression percentage of CTL cell(CD8+ICOS+CD3+)were(1.57±1.99)vs(0.02±0.04)%, P＜0.01;expression percentage of CD8+inhibitory T cell(CD8+ICOS-CD3+)ratio were(16.6±6.94)vs(20.56±6.54)%, P＜0.05.No difference of expression was found in peripheral T cell subpopulations of postoperative patients with gastric cancer after one week(P＞0.05).Conclusion T cell number decreased, and T cell costimulatory molecule ICOS expression incrensed in patients with gastric cancer.CD4+T cell subpopulation is significantly decreased in patients with gastric cancer.

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