塞来昔布和谷氨酰胺保护癌性恶病质肠粘膜屏障机制探讨

doi:10.3969/j.issn.1002-3070.2013.03.013

PRACTICAL ONCOLOGY JOURNAL ›› 2013, Vol. 27 ›› Issue (3): 246-250.doi: 10.3969/j.issn.1002-3070.2013.03.013

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The protection of cancer cachexia mice from intestinal mucosal injury by Celecoxib

JIA Yunhe¹,LI Mingqi¹,XUE Weinan¹,SUN Zicheng¹,WANG Yihui¹,DONG wei¹,WANG Ping¹,ZHU Lei¹,JIANG Zhiwei²

1.Department of Colorectal Surgery,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China;
2.Nanjing General Hospital of Nanjing Military Command,Army Research Institute of General Surgery

Received:2013-01-04 Online:2013-06-28 Published:2013-07-04

Abstract

Abstract: Objective To discuss the protection mechanism of intestinal mucosal injury by Celecoxib and glutamine of cancer cachexia mice.Methods 28 mice were divided into four groups randomly.The weight loss,the height and width of intestinal villi as well as the thickness of muscular layer and basal layer were compared in these groups.The inflammatory cytokines in the mucous membrane and blood serum were tested.Results The body weight loss and mucous membrane of small intestine atrophy were inhibited by Celecoxib and glutamine.TNF and IL-6 expressions decreased,and sTNFRⅠand IL-10 expressions increased in blood serum.INFγ lerel increased in mucous membrane after treated by the Celecoxib and glutamine.Conclusion Celecoxib and glutamine can protect the weight loss by inhibiting the inflammation in cancer cachexia mice.

CLC Number:

R735

JIA Yunhe,LI Mingqi,XUE Weinan,SUN Zicheng,WANG Yihui,DONG wei,WANG Ping,ZHU Lei,JIANG Zhiwei. The protection of cancer cachexia mice from intestinal mucosal injury by Celecoxib[J]. PRACTICAL ONCOLOGY JOURNAL, 2013, 27(3): 246-250.

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The protection of cancer cachexia mice from intestinal mucosal injury by Celecoxib

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