Abstract: Abstract Osteosarcoma is a common malignant bone tumor in the skeletal system of minors. The five-year survival rate of patients with osteosarcoma is significanty improved by neoadjuvant chemotherapy combined with surgery. However, its mortality and morbidity rates remain quite high. With the development of molecular biology and genetics, gene therapy provides a new hope for patients with osteosarcoma. Researchers at home and abroad are actively exploring effective therapeutic targets. In this paper, new progress in the study of gene-targeted therapy for osteosarcoma is reviewed.

Key words: Osteosarcoma , Gene-targeted therapy