Abstract: Ovarian cancer is the highest mortality in the female genital malignancies.Because no obvious symptoms of early ovarian cancer,it is found 70% of patients with advanced.Therefore,early detection of ovarian cancer,early treatment and personalized treatment programs is the development direction of cancer treatment.Metabolomics as an emerging technology for the early diagnosis of ovarian cancer,the efficacy evaluation and prognosis has opened up a new window.Metabolomics can make a comprehensive evaluation of changes in metabolism,screened valuable biomarker for early diagnosis and treatment of tumors,treatment and prognosis.In this paper,we reviewed the concepts and Methods of metabolomics as well as metabolomics in the early diagnosis of ovarian cancer,pathological type and targeted therapy applications.