Abstract: Objective To evaluate the molecule mechanisms efficacy of two neoadjuvant chemotherapys(NACT)on locally advanced cervix cancer(LACC), and according to this for selecting treatment way.Methods 40 patients, which had been divided into two groups, were treated with two cycles of cisplatin combined with ifosfomide or cisplatin combined with paclitaxol, meanwhile, Ki-67、apoptosis index(AI)and survivin were detected and assayed with flow cytometry and TUNEL.Results The clinical efficacy rates of the two groups were 75%(IP group)and 95%(TP group)respectively, there was statistical difference(P＜0.05).Significant difference of Ki-67、survivin and AI could be observed before and after NACT(P＜0.05).Conclusion Two kinds of NACT could inhibit proliferation and increase apoptosis of tumor cells in cervical squamous carcinoma tissue.The clinical efficacy and molecule treatment efficacy of the group IP is equal to the group TP, but the latter need a shorter time of treating and in the hospital, so the patients are easy to take it and we should be encouraged to adopt it.

Key words: Cervical cancer, Neoadjuvant chemotherapy, Proliferating cell nuclear antigen, Apoptosis index, Survivin