大肠癌中CD133、COX-2的表达及DNA倍体的研究

doi:10.11904/j.issn.1002-3070.2016.03.002

Abstract

Abstract: Objective To detect the expression of CD133,COX-2 and the state of DNA ploidy in colorectal carcinoma;to investigate the relationship of between these factors and clinicopathological characteristics of colorectal carcinoma,and the correlationship between of these factors.Methods Immunohistochemical SP method was performed to detect CD133and COX-2 in 90 cases of colorectal carcinoma and in 90 cases of normal intestinal mucosal,the detection of DNA ploidy was examined by flow cytometry method(FCM).Results The positive expression of CD133,COX-2 and DNA ploidy in colorectal cancer were significant higher than that in normal intestinal mucosa(P＜0.05);the expression of CD133 was positive correlated to the degree of differentiation and lymphoid metastasis in colorectal cancer(P＜0.05);and the expressions of COX-2 was positive correlated to TNM staging and lymphoid metastasis(P＜0.05);the positive expression of CD133,COX-2 and DNA ploidy rates were positive correlated with each other(P＜0.01).Conclusion The CD133,COX-2 and DNA ploidy in colorectal carcinoma were high expressed and positive correlated with each other,these results indicated that these factors may relate with the occurrence and development of colorectal cancer,and may provide an important basis for the clinical treatment and research.

Key words: Colorectal cancer, CD133, COX-2, DNA ploidy

CLC Number:

R739.96

WANG Qian,CHEN Tielong,LUO Wei,WANG Caiqin. Research of CD133,COX-2 expressions and DNA ploidy in colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(3): 200-206.

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Research of CD133,COX-2 expressions and DNA ploidy in colorectal cancer

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