伏核微量注射异丁司特对吗啡成瘾大鼠甩尾痛阈的影响

doi:10.11904/j.issn.1002-3070.2019.03.004

Abstract

Abstract: Objective The aim of this study was to investigate the effect of microinjection ibudilast on the appendix pain threshold in nucleus accumbens(NAC)of morphine-addicted rats.Methods Normal rats and morphine-addicted rats were injected with ibudilast(5 μg/2 μL)or saline(2 μL)into NAC through glass microelectrode.The tail-flick period(TFL)was used as an indicator to observe the thermal pain threshold before and after ibuilast injection.Results After injected ibudilast 5 μg into the NAC of normal rats and morphine-added rats,the TFL was prolonged compared with that before injection,and the TFL prolongation of morphine-addicted rats was more significant than that of normal rats.There was no significant change in TFL after 2 μL of saline was injected into the NAC of normal rats and morphine-addicted rats.Conclusion Microinjection of ibudilast into NAC of normal rats and morphine-added rats can cause analgesic effect,and the analgesic effect of morphine-addicted rats is more significant.

Key words: Nucleus accumbens, Ibudilast, Morphine-addicted, Tail-flick latency

CLC Number:

XU Qiuju,ZHANG Guangwen. Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats[J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 211-214.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2019.03.004

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References 1

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Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats

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