抑癌基因ING3在大肠癌中表达及意义

doi:10.11904/j.issn.1002-3070.2014.06.001

实用肿瘤学杂志 ›› 2014, Vol. 28 ›› Issue (6): 481-484.doi: 10.11904/j.issn.1002-3070.2014.06.001

• 论著 • 下一篇

抑癌基因ING3在大肠癌中表达及意义

崔滨滨, 刘彦龙, 陈洪生, 周飞, 于雪峰, 徐海涛

哈尔滨医科大学附属肿瘤医院结直肠外科(哈尔滨 150081)

收稿日期:2014-09-07 出版日期:2014-12-28 发布日期:2015-01-08
通讯作者: 崔滨滨,E-mail:drcbb222@163.com
作者简介:崔滨滨,男,(1967-),博士,主任医师,从事大肠癌基础与临床的研究
基金资助:
黑龙江省教育厅科学技术研究面上项目(11541129)

The expression and significance of ING3 in colorectal cancer

CUI Binbin,LIU Yanlong,CHEN Hongsheng,ZHOU Fei,YU Xuefeng,XU Haitao

Department of Colorectal Surgery,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2014-09-07 Online:2014-12-28 Published:2015-01-08

摘要/Abstract

摘要：

目的探讨ING3在大肠癌中的表达及意义。方法收集82例大肠癌临床手术标本,通过荧光定量PCR检测癌旁正常黏膜中与癌组织中ING3的表达水平,分析ING3的表达水平与临床病理特征及预后的关系。结果 51%的大肠癌患者中,ING3 mRNA在癌组织中的表达水平显著低于癌旁组织,ING3的表达与临床T分期、M分期及TNM分期密切相关(P＜0.05)。单因素分析显示出T、N、M分期、TNM分期及ING3的表达均与患者术后总无病生存率相关(P＜0.05)。ING3低表达组患者长期无病生存率较中高表达组患者显著降低(P＜0.05)。结论 ING3的表达与大肠癌发生发展相关,有望成为大肠癌早期诊断早期治疗的分子靶点。

关键词: 抑癌基因, 人类生长抑制因子3, 大肠癌

Abstract:

Objective Inhibitor of growth TNG3 is a candidate tumor suppressor gene,which belongs to the human ING gene family.It has been interested by scientist because of its putative roles as tumor suppressors.There is a low expression level of ING3 in a variety of tumors.However,the relationship of ING3 and the development of colorectal cancer is unclear yet.The aim of this studyis to examine the expression of ING3 in colorectal cancer by qRT-PCR.Methods Statistical analysis was performed with the expression of ING3 mRNA which has been evaluated in 82 matched samples comprising primary colorectal cancer and paired non-cancerous mucosa samples.Results In 51% colorectal cancer patients,the expression level of ING3 was significantly lower in cancer tissue than that in normal tissue.The expression level of ING3 was closely related to pT、pM stage,and TNM stage(P＜0.05).The Univariate analysis showed that the pT、pN、pM stage,TNMstage and ING3 expression levels were associated with disease-free survival(P＜0.05).CRC patients with low-expression level of ING3 showed shorter disease-free survivals(P＜0.05).Conclusion The expression of ING3 might contribute to the CRC development or progression.

Key words: Tumor suppressor gene, ING3, Colorectal cancer

中图分类号:

R735.3⁺4

崔滨滨, 刘彦龙, 陈洪生, 周飞, 于雪峰, 徐海涛. 抑癌基因ING3在大肠癌中表达及意义[J]. 实用肿瘤学杂志, 2014, 28(6): 481-484.

CUI Binbin,LIU Yanlong,CHEN Hongsheng,ZHOU Fei,YU Xuefeng,XU Haitao. The expression and significance of ING3 in colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 481-484.

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抑癌基因ING3在大肠癌中表达及意义

The expression and significance of ING3 in colorectal cancer

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