MMP-7在非小细胞肺癌中的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.020

摘要/Abstract

摘要： 肺癌是当今世界最常见的恶性肿瘤之一,其中约85%为非小细胞肺癌,发病机制至今尚不明确。基质金属蛋白酶(MMPs)是一组能降解细胞外基质和基底膜的蛋白溶解酶家族,各成员具有相似的结构及一定的底物特异性。有研究显示基质金属蛋白酶家族中的基质金属蛋白酶7(MMP-7)参与了非小细胞肺癌的浸润和转移,在非小细胞肺癌组织中MMP-7的表达明显高于癌旁组织,且MMP-7对非小细胞肺癌患者的预后评估亦有重要意义。因此,本文就MMP-7结构、功能、表达的调节等几个方面进行综述。

关键词: 基质金属蛋白酶7, 肺癌, 侵袭, 转移

Abstract: Lung cancer is one of the most common malignant tumors in the world.Non-small lung cancer(NSCLC)accounts for approximately 85%,but its pathogenesis has not been elucidated.As a family of soluble enzymes,matrix metalloproteinases(MMPs)can degrade the constituents of the extracellular matrix(ECM)and the basement-membrane,members share common structural features and are responsible for the relative specific substrates.Some researches show that the matrix metalloproteinases 7(MMP-7)involve in the invasion and metastasis of NSCLC,the expression of MMP-7 in the tissue of NSCLC is significcantly higher than that in adjacent tissues,and the MMP-7 plays important roles in prognosis evaluation of NSCLC patients.Therefore this paper summarize the domain structure,function,regulation and research in NSCLC about MMP-7.

Key words: Matrix metalloproteinases7, Lung cancer, Invasion, Metastasis

中图分类号:

R734.2

孙希综述, 刘宝刚审校. MMP-7在非小细胞肺癌中的研究进展[J]. 实用肿瘤学杂志, 2016, 30(1): 93-96.

SUN Xi, LIU Baogang. Research progress of MMP-7 in non-small lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 93-96.

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