非编码RNA在膀胱癌中的研究进展

doi:10.11904/j.issn.1002-3070.2020.06.016

摘要/Abstract

摘要： 膀胱癌是全世界最常见的癌症之一,虽然手术结合化疗和放疗在一定程度上改善了患者的预后,但大多数肌肉浸润性膀胱癌患者的预后仍然很差。而且,膀胱癌的确切机制和关键调节因子尚不清楚。最近的研究表明,一些非编码RNA在膀胱癌中表达失调,对膀胱癌的发生发展起着至关重要的作用。更重要的是,非编码RNA可作为膀胱癌的诊断和预后的生物标志物。本综述旨在总结近期的研究进展,这些研究表明了包括miRNA、lncRNA、circRNA在内的三类非编码RNA在膀胱癌中的调控机制,以及它们作为临床诊断或预后生物标志物的潜在作用。

关键词: 膀胱癌, miRNA, lncRNA, circRNA

Abstract: Bladder cancer is one of the most common cancers in the world.Although the prognosis of patients to a certain extent has been improved by surgery combined with chemotherapy and radiotherapy,the prognosis of most patients with muscle-invasive bladder cancer is still poor.Moreover,the exact mechanism and key regulators of bladder cancer are unclear.Recent studies have shown that some non-coding RNAs are dysregulated in bladder cancer and play crucial roles in the development of bladder cancer.More importantly,non-coding RNA can be used as a biomarker for the diagnosis and prognosis of bladder cancer.This review aims to summarize recent research progress,which indicate the regulatory mechanisms for three types of non-coding RNAs including miRNA,lncRNA,and circRNA in bladder cancer,and their potential roles as biomarkers for clinical diagnosis or prognosis.

Key words: Bladder cancer, miRNA, lncRNA, circRNA

中图分类号:

R737.14

李荣迪, 李学东. 非编码RNA在膀胱癌中的研究进展[J]. 实用肿瘤学杂志, 2020, 34(6): 565-570.

LI Rongdi, LI Xuedong. Research progress of non-coding RNA in bladder cancer[J]. Journal of Practical Oncology, 2020, 34(6): 565-570.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2020.06.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2020/V34/I6/565

参考文献

1 Hall MC,Chang SS,Dalbagni G,et al.Guideline for the management of nonmuscle invasive bladder cancer(stages Ta,T1,and Tis):2007 update[J].J Urol,2007,178(6):2314-2330.
2 Kaufman DS,Shipley WU,Feldman AS.Bladder cancer[J].Lancet,2009,374(9685):239-249.
3 Dudderidge TJ.Urinary markers in bladder cancer[J].BJU Int,2003,92(7):823-824.
4 Geng Y,Jiang J,Wu C.Function and clinical significance of circRNAs in solid tumors[J].J Hematol Oncol,2018,11(1):98.
5 Xu C,Zeng Q,Xu W,et al.miRNA-100 inhibits human bladder urothelial carcinogenesis by directly targeting mTOR[J].Mol Cancer Ther,2013,12(2):207-219.
6 Friedman JM,Liang G,Liu CC,et al.The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2[J].Cancer Res,2009,69(6):2623-2629.
7 柳清,尤泊森,马景光,等.MicroRNA-30a在膀胱癌中的表达及作用[J].实用肿瘤学杂志,2017,31(4):310-315.
8 Lin Y,Chen H,Hu Z,et al.miR-26a inhibits proliferation and motility in bladder cancer by targeting HMGA1[J].FEBS Lett,2013,587(15):2467-2473.
9 Xu T,Qin L,Zhu Z,et al.MicroRNA-31 functions as a tumor suppressor and increases sensitivity to mitomycin-C in urothelial bladder cancer by targeting integrin alpha5[J].Oncotarget,2016,7(19):27445-27457.
10 Majid S,Dar AA,Saini S,et al.MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder cancer[J].PLoS One,2013,8(7):67686.
11 Chiyomaru T,Enokida H,Tatarano S,et al.miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer[J].Br J Cancer,2010,102(5):883-891.
12 Cao Y,Yu SL,Wang Y,et al.MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24[J].Tumour Biol,2011,32(1):179-188.
13 Du M,Shi D,Yuan L,et al.Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer[J].Sci Rep,2015,5:10437.
14 Liu X,Liu X,Wu Y,et al.MicroRNA-34a attenuates metastasis and chemoresistance of bladder cancer cells by targeting the TCF1/LEF1 Axis[J].Cell Physiol Biochem,2018,48(1):87-98.
15 Kriebel S,Schmidt D,Holdenrieder S,et al.Analysis of tissue and serum microRNA expression in patients with upper urinary tract urothelial cancer[J].PLoS One,2015,10(1):e0117284.
16 Mearini E,Poli G,Cochetti G,et al.Expression of urinary miRNAs targeting NLRs inflammasomes in bladder cancer[J].Onco Targets Ther,2017,10:2665-2673.
17 Sasaki H,Yoshiike M,Nozawa S,et al.Expression level of urinary MicroRNA-146a-5p is increased in patients with bladder cancer and decreased in those after transurethral resection[J].Clin Genitourin Cancer,2016,14(5):493-499.
18 Pignot G,Vieillefond A,Vacher S,et al.Hedgehog pathway activation in human transitional cell carcinoma of the bladder[J].Br J Cancer,2012,106(6):1177-1186.
19 Pospisilova S,Pazourkova E,Horinek A,et al.MicroRNAs in urine supernatant as potential non-invasive markers for bladder cancer detection[J].Neoplasma,2016,63(5):799-808.
20 Hirata H,Ueno K,Shahryari V,et al.Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder cancer[J].PLoS One,2012,7(11):51056.
21 Feng C,Sun P,Hu J,et al.miRNA-556-3p promotes human bladder cancer proliferation,migration and invasion by negatively regulating DAB2IP expression[J].Int J Oncol,2017,50(6):2101-2112.
22 Wang R,Wu Y,Huang W,et al.MicroRNA-940 targets INPP4A or GSK3beta and activates the Wnt/beta-Catenin pathway to regulate the malignant behavior of bladder cancer cells[J].Oncol Res,2018,26(1):145-155.
23 Nordentoft I,Birkenkamp-Demtroder K,Agerbaek M,et al.miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer[J].BMC Med Genomics,2012,5(1):1-11.
24 Kozinn SI,Harty NJ,Delong JM,et al.MicroRNA profile to predict gemcitabine resistance in bladder carcinoma cell Lines[J].Genes Cancer,2013,4(1/2):61-69.
25 Long JD,Sullivan TB,Humphrey J,et al.A non-invasive miRNA based assay to detect bladder cancer in cell-free urine[J].Am J Transl Res,2015,7(11):2500-2509.
26 Mengual L,Lozano JJ,Ingelmo-Torres M,et al.Using microRNA profiling in urine samples to develop a non-invasive test for bladder cancer[J].Int J Cancer,2013,133(11):2631-2641.
27 Du L,Jiang X,Duan W,et al.Cell-free microRNA expression signatures in urine serve as novel noninvasive biomarkers for diagnosis and recurrence prediction of bladder cancer[J].Oncotarget,2017,8(25):40832-40842.
28 Neely LA,Rieger-Christ KM,Neto BS,et al.A microRNA expression ratio defining the invasive phenotype in bladder tumors[J].Urol Oncol,2010,28(1):39-48.
29 Wei Z,Hu X,Liu J,et al.MicroRNA-497 upregulation inhibits cell invasion and metastasis in T24 and BIU-87 bladder cancer cells[J].Mol Med Rep,2017,16(2):2055-2060.
30 Martinez-Fernandez M,Duenas M,Feber A,et al.A Polycomb-mir200 loop regulates clinical outcome in bladder cancer[J].Oncotarget,2015,6(39):42258-42275.
31 Guo Y,Zhang H,Xie D,et al.Non-coding RNA NEAT1/miR-214-3p contribute to doxorubicin resistance of urothelial bladder cancer preliminary through the Wnt/beta-catenin pathway[J].Cancer Manag Res,2018,10:4371-4380.
32 Chen M,Zhuang C,Liu Y,et al.Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer[J].Cancer Lett,2016,376(1):155-164.
33 Fan Y,Shen B,Tan M,et al.TGF-beta-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12[J].Clin Cancer Res,2014,20(6):1531-1541.
34 Iliev R,Kleinova R,Juracek J,et al.Overexpression of long non-coding RNA TUG1 predicts poor prognosis and promotes cancer cell proliferation and migration in high-grade muscle-invasive bladder cancer[J].Tumour Biol,2016,37(10):13385-13390.
35 Tan J,Qiu K,Li M,et al.Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells[J].Febs Letters,2015,589(20 Pt B):3175-3181.
36 Liu Q,Liu H,Cheng H,et al.Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1/miR-142/ZEB2 axis in bladder cancer cells[J].Onco Targets Ther,2017,10:2461-2471.
37 Ye T,Ding W,Wang N,et al.Long noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer[J].Biochem Biophys Res Commun,2017,491(1):79-84.
38 Luo M,Li Z,Wang W,et al.Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression[J].Cancer Lett,2013,333(2):213-221.
39 Duan W,Du L,Jiang X,et al.Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer[J].Oncotarget,2016,7(48):78850-78858.
40 Zhang H,Guo Y,Song Y,et al.Long noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma[J].Cancer Chemother Pharmacol,2017,79(1):49-55.
41 Liu Z,Wang W,Jiang J,et al.Downregulation of GAS5 promotes bladder cancer cell proliferation,partly by regulating CDK6[J].PLoS One,2013,8(9):e73991.
42 Cao Q,Wang N,Qi J,et al.Long noncoding RNAGAS5 acts as a tumor suppressor in bladder transitional cell carcinoma via regulation of chemokine(CC motif)ligand 1 expression[J].Mol Med Rep,2016,13(1):27-34.
43 Wang YY,Wu ZY,Wang GC,et al.LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p[J].Tumour Biol,2016,37(11):14553-14563.
44 Zhu Y,Dai B,Zhang H,et al.Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis[J].Cancer Lett,2016,380(2):369-374.
45 Chen T,Xie W,Xie L,et al.Expression of long noncoding RNA lncRNA-n336928 is correlated with tumor stage and grade and overall survival in bladder cancer[J].Biochem Biophys Res Commun,2015,468(4):666-670.
46 Li LJ,Zhu JL,Bao WS,et al.Long noncoding RNA GHET1 promotes the development of bladder cancer[J].Int J Clin Exp Pathol,2014,7(10):7196-7205.
47 He A,Liu Y,Chen Z,et al.Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer[J].J Exp Clin Cancer Res,2016,35(1):125.
48 Zhong Z,Huang M,Lv M,et al.Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway[J].Cancer Lett,2017,403:305-317.
49 Zhong Z,Lv M,Chen J.Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma[J].Sci Rep,2016,6:30919.
50 Yang C,Wu S,Wu X,et al.Silencing circular RNA UVRAG inhibits bladder cancer growth and metastasis by targeting the microRNA-223/fibroblast growth factor receptor 2 axis[J].Cancer Sci,2019,110(1):99-106.
51 Wu Z,Huang W,Wang X,et al.Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11[J].Mol Med,2018,24(1):40.
52 Zhang X,Liu X,Jing Z,et al.The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer[J].Cancer Gene Ther,2020,27(314):189-202.
53 Li P,Yang X,Yuan W,et al.CircRNA-Cdr1as exerts anti-oncogenic functions in bladder cancer by sponging MicroRNA-135a[J].Cell Physiol Biochem,2018,46(4):1606-1616.
54 Li Y,Zheng F,Xiao X,et al.CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells[J].EMBO Rep,2017,18(9):1646-1659.
55 Xie F,Li Y,Wang M,et al.Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis[J].Mol Cancer,2018,17(1):144.
56 Zeng Z,Zhou W,Duan L,et al.Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway[J].J Cell Physiol,2019,234(4):3887-3896.
57 Huang W,Lu Y,Wang F,et al.Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression[J].Gene,2018,678:337-342.
58 Bi J,Liu H,Cai Z,et al.Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p/RAB27A axis[J].Aging(Albany NY),2018,10(8):1964-1976.
59 Chen X,Chen RX,Wei WS,et al.PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition[J].Clin Cancer Res,2018,24(24):6319-6330.
60 Li Y,Wan B,Liu L,et al.Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition[J].Biochem Biophys Res Commun,2019,508(4):991-996.
61 Yang C,Yuan W,Yang X,et al.Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21,PTEN expression[J].Mol Cancer,2018,17(1):19.
62 Liu H,Chen D,Bi J,et al.Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer[J].Aging(Albany NY),2018,10(10):2606-2623.
63 Lin G,Sheng H,Xie H,et al.circLPAR1 is a novel biomarker of prognosis for muscle-invasive bladder cancer with invasion and metastasis by miR-762[J].Oncol Lett,2019,17(3):3537-3547.

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