RNA结合蛋白Lin28在恶性肿瘤发生发展中的作用和分子机制

doi:10.11904/j.issn.1002-3070.2019.05.014

摘要/Abstract

摘要： RNA结合蛋白Lin28在多种恶性肿瘤组织中表达。某些转录因子和RNA结合蛋白可以在转录水平和转录后水平上调Lin28的表达。而高水平的Lin28可以通过影响miRNA的表达或调控靶mRNA的转录、剪接、稳定性和翻译等过程来诱导正常细胞恶性转化,并可对肿瘤细胞的增殖和转移等过程产生促进作用。Lin28高表达具有诱导肿瘤发生和进展的重要作用,同时也是评估恶性肿瘤预后状态的重要生物学标志。本综述总结现有文献内容,对Lin28在恶性肿瘤中的作用、上调的分子机制和发挥作用时的下游调控机制进行了概括,对充分认识Lin28分子具有重要意义。

关键词: Lin28, 恶性肿瘤, 分子机制

Abstract: The RNA binding protein Lin28 is expressed in a variety of malignant tumor tissues.The certain transcription factors and RNA binding proteins can up-regulate the expression of Lin28 at both transcription and post-transcription levels.The high level of Lin28 can induce malignant transformation of normal cells by affecting the expression of miRNA or regulating the transcription,splicing,stability and translation of target mRNA,and can promote the proliferation and metastasis of tumor cells.The high expression of Lin28 has an important role in inducing tumorigenesis and progression,and is also an important biomarker for assessing the prognosis of malignant tumors.This review summarizes the existing literature about the role of Lin28 in malignant tumors,the molecular mechanisms of upregulation,and the downstream regulatory mechanisms at the time of action,which is of great significance for fully understanding the Lin28 molecule.

Key words: Lin28, Malignant tumor, Molecular mechanism

中图分类号:

R730.2

李亚飞, 张霄, 王雪飞, 翁明娇, 王天真. RNA结合蛋白Lin28在恶性肿瘤发生发展中的作用和分子机制[J]. 实用肿瘤学杂志, 2019, 33(5): 456-460.

LI Yafei, ZHANG Xiao, WANG Xuefei, WENG Mingjiao, WANG Tianzhen. Effect of RNA-binding protein Lin28 on the development of malignant tumors and its molecular mechanism[J]. Journal of Practical Oncology, 2019, 33(5): 456-460.

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链接本文: http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/10.11904/j.issn.1002-3070.2019.05.014

http://journal09.magtechjournal.com/Jwk3_syzlxzz/CN/Y2019/V33/I5/456

参考文献

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