Abstract: Multiple primary gastrointestinal tract cancer is the most common multiple primary cancer in China.Contrasted with single cancer,missed and misdiagnosis of multiple primary cancers may affect the choice of surgical approach,treatment effect and prognosis directly.Multiple primary upper gastrointestinal tract cancers(MPUGICs)as multiple cancers occur in the same organ or in different organs of upper gastrointestinal tract.The detection of MPUGICs is various from reports in China.This article reviews recent literatures on diagnose,pathogenesis,clinical feature,therapy and prognosis of MPUGICs in order to improve clinician′s awareness of multiple primary upper gastrointestinal tract cancers.