抑癌基因ING3在大肠癌中表达及意义

doi:10.11904/j.issn.1002-3070.2014.06.001

Abstract

Abstract:

Objective Inhibitor of growth TNG3 is a candidate tumor suppressor gene,which belongs to the human ING gene family.It has been interested by scientist because of its putative roles as tumor suppressors.There is a low expression level of ING3 in a variety of tumors.However,the relationship of ING3 and the development of colorectal cancer is unclear yet.The aim of this studyis to examine the expression of ING3 in colorectal cancer by qRT-PCR.Methods Statistical analysis was performed with the expression of ING3 mRNA which has been evaluated in 82 matched samples comprising primary colorectal cancer and paired non-cancerous mucosa samples.Results In 51% colorectal cancer patients,the expression level of ING3 was significantly lower in cancer tissue than that in normal tissue.The expression level of ING3 was closely related to pT、pM stage,and TNM stage(P＜0.05).The Univariate analysis showed that the pT、pN、pM stage,TNMstage and ING3 expression levels were associated with disease-free survival(P＜0.05).CRC patients with low-expression level of ING3 showed shorter disease-free survivals(P＜0.05).Conclusion The expression of ING3 might contribute to the CRC development or progression.

Key words: Tumor suppressor gene, ING3, Colorectal cancer

CLC Number:

R735.3⁺4

CUI Binbin,LIU Yanlong,CHEN Hongsheng,ZHOU Fei,YU Xuefeng,XU Haitao. The expression and significance of ING3 in colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 481-484.

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The expression and significance of ING3 in colorectal cancer

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