PRACTICAL ONCOLOGY JOURNAL ›› 2014, Vol. 28 ›› Issue (6): 565-568.doi: 10.11904/j.issn.1002-3070.2014.06.018

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Research progress of HIF-1 in cancers

ZHANG Bo,ZHAO Gang   

  1. Department of Orthopedics,Fuling Central Hospital,Chongqing 408000,China
  • Received:2014-07-26 Online:2014-12-28 Published:2015-01-08

Abstract:

Transcription factorhypoxia inducible factor-1(HIF-1)plays a key role in cell adaption to hypoxia(from 21% O2 to 1% O2).Researches have shown that HIF-1 is closely related to occurrence and development in many malignant cancers.In this paper,we review the effect of HIF-1 in tumor growth,metastasis,apoptosis and angiogenesis.

Key words: Hypoxia, HIF-1, Neoplasms

CLC Number: