核心蛋白聚糖基因在肿瘤学中的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.009

Abstract

Abstract: Decorin(DCN)is one of the leucine-rich proteoglycan family of small molecules.It is recognized as a tumor suppressor gene.DCN can inhibit tumor cell proliferation and metastasis by binding and inactivation of transforming growth factor beta(TGF-β)and inhibiting the expression of vascular endothelial growth factor or by activating the signaling pathway that promotes cell proliferation by EGFR/MAPK/p21.it plays an important effect on tumor development,angiogenesis and metastasis.DCN is expressed in various malignant tumors,By up or down regulation,DCN can exert its anti tumor activity,as well as reducing or delaying the occurrence and development of many kinds of malignant tumor.DCN gene may be a potential target for the treatment of many kinds of malignant tumors.

Key words: Decorin, Gene, Tumor, Progress

CLC Number:

R730.55

WANG Li, XU Qingyong. Research progress of decorin gene in oncology[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 44-47.

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Research progress of decorin gene in oncology

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