KIF14在恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2016.03.018

Abstract

Abstract: KIF14 as kinesin superfamily(KIFS)member,by adjusting the mitotic spindle formation,chromosome separation and cytokinesis completion,thereby promotes tumor development and progression.KIF14 abnormalities has been demonstrated in a variety of human malignancies,enhanced its role can affect the mitosis process and result in the occurrence of tumor;To reduce its effect can lead to inactivation of the kinase AKT,thereby reducing the migration of cells and promote apoptosis.In addition,the lack of KIF14 may also enhance tumor sensitivity to chemotherapy.In summary,KIF14 played an important role in cancer development and progression.This paper reviews the relationship between KIF14 and malignant tumors.

Key words: Kinesin family member 14, Mitosis, Cancer, Invasion, Metastasis

CLC Number:

HUANG Yuxin,GENG Jingshu. The research progresses on KIF14 in malignant tumors[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(3): 279-283.

References

1 Stevens KN,Wang X,Fredericksen Z,et al.Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer[J].Breast Cancer Res Treat,2011,129(2):617-622.
2 Gao J,Sai N,Wang C,et al.Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo[J].Tumour Biol,2011,32(1):53-61.
3 Haruki T,Maeta Y,Nakamura S,et al.Advanced cancer with situs inversus totalis associated with KIF3 complex deficiency:report of two cases[J].Surg Today,2010,40(2):162-166.
4 Hung PF,Hong TM,Hsu YC,et al.The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma[J].PLoS One,2013,8(4):e61664.
5 Hirokawa N,Tanaka Y.Kinesin superfamily proteins(KIFs):Various functions and their relevance for important phenomena in life and diseases[J].Exp Cell Res,2015,334(1):16-25.
6 Corson TW,Gallie BL.KIF14 mRNA expression is a predictor of grade and outcome in breast cancer[J].Int J Cancer,2006,119(5):1088-1094.
7 Miki H,Okada Y,Hirokawa N.Analysis of the kinesin superfamily:insights into structure and function[J].Trends Cell Biol,2005,15(9):467-476.
8 Nomura N,Nagase T,Miyajima N,et al.Prediction of the coding sequences of unidentified human genes Ⅱ The coding sequences of 40 new genes(KIAA0041-KIAA0080)deduced by analysis of cDNA clones from human cell line KG-1[J].DNA Res,1994,1(5):223-229.
10 Zhu C,Zhao J,Bibikova M,et al.Functional analysis of human microtubule-based motor proteins,the kinesins and dyneins,in mitosis/cytokinesis using RNA interference[J].Mol Biol Cell,2005,16(7):3187-3199.
11 Gruneberg U,Neef R,Li X,et al.KIF14 and citron kinase act together to promote efficient cytokinesis[J].J Cell Biol.2006,172(3):363-372.
12 Carleton M,Mao M,Biery M,et al.RNA interference mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure[J].Mol Cell Biol,2006,26(10):3853-3863.
13 Huang M,Anand S,Murphy EA,et al.EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation[J].Oncogene,2012,31(22):2783-2793.
14 Ahmed SM,Thériault BL,Uppalapati M,et al.KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression[J].J Cell Bio,2012,199(6):951-967.
15 Taylor LP.Diagnosis treatment,and prognosis of glioma:five new things[J].Neurology,2010,75(18):28-32.
16 Wang Q,Wang L,Li D,et al.Kinesin family member 14 is a candidate prognostic marker for outcome of glioma patients[J].Cancer Epidemiology,2013,37(1):79-84.
17 Huang W,Wang J,Zhang D,et al.Inhibition of KIF14 suppresses tumor cell growth and promotes apoptosis in human glioblastoma[J].Cell Physiol Biochem,2015,37(5):1659-1670.
18 Singel SM,Cornelius C,Zaganjor E,et al.KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer[J].Neoplasia,2014,16(3):247-256.
19 Shah SP,Roth A,Goya R,et al.The clonal and mutational evolution spectrum of primary triple-negative breast cancers[J].Nature,2012,486(7403):395-399.
20 Singel SM,Cornelius C,Batten K,et al.A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer[J].Clin Cancer Res,2013,19(8):2061-2070.
21 Corson TW,Huang A,Tsao MS,et al.KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers[J].Oncogene,2005,24(30):4741-4753.
22 Madhavan J,Coral K,Mallikarjuna K,et al.High expression of KIF14 in retinoblastoma:association with older age at diagnosis[J].Invest Ophthalmol Vis Sci,2007,48(11):4901-4906.
23 Pajovic S,Corson TW,Spencer C,et al.The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties[J].Invest Ophthalmol Vis Sci,2011,52(10):7618-7624.
24 Basavarajappa HD,Corson TW.KIF14 as an oncogene in retinoblastoma:a target for novel therapentics[J].Future Med Chem,2012,4(17):2149-2152.
25 Thériault BL,Pajovic S,Bernardini MQ,et al.Kinesin family member 14:an independent prognostic marker and potential therapeutic target for ovarian cancer[J].Int J Cancer,2012,130(8):1844-1854.
26 Thériault BL,Cybulska P,Shaw PA,et al.The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells[J].J Ovarian Res,2014,7:123-131.
27 Ehrlichova M,Mohelnikova-Duchonova B,Hrdy J,et al.The association of taxane resistance genes with the clinical course of ovarian carcinoma[J].Genomics,2013,102(2):96-101.
28 Thériault BL,Basavarajappa HD,Lim H,et al.Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer[J].PLoS One,2014,9(3):e91540.
29 Corson TW,Zhu CQ,Lau SK,et al.KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer[J].Clin Cancer Res,2007,13(11):3229-3234.
30 Yang T,Zhang XB,Zheng ZM.Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome[J].Cancer Sci,2013,104(5):552-557.
31 Xu H,Choe C,Shin SH,et al.Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27Kip1 ubiquitination pathway in hepatocellular carcinoma[J].Exp Mol Med,2014,46(5):e97.
32 Yang T,Li XN,Li L,et al.Sox17 inhibits hepatocellular carcinoma progression by down-regulation of KIF14 expression[J].Tumor Biol,2014,35(11):11199-11207.
33 陈宗营,马恒.KIF14在胃癌中的表达及其意义[J].中国现代普通外科进展,2011,14(12):941-944.

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The research progresses on KIF14 in malignant tumors

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