MicroRNA和NF-κB与胃癌侵袭转移关系的研究进展

doi:10.11904/j.issn.1002-3070.2016.04.017

Abstract

Abstract: MiRNA is a class of small endogenous non-coding molecule RNA with regulatory functions,which regulates the target genes at the post-transcriptional level by binding with 3′untranslated regions(3′UTR)specifically.Nuclear factor kappaB(NF-κB)is a kind of significant intranuclear transcription factor.Being activized,it easily combines with the fixed nucleotide sequence in promoter region to initiate gene transcription and participates in the invasion and metastasis of gastric cancer.Recent researches showed that miRNA not only influences on tumor invasion and metastasis by regulating the expression of downstream target gene NF-κB,and itself also could be regulated by NF-κB transcription factors.This essay mainly narrates the expression of microRNA and NF-κB in gastric carcinoma,and summarize the influence to the invasion and metastasis of gastric cancer cells by regulating thier expression interction.

Key words: Gastric cancer, MicroRNA, NF-κB

CLC Number:

R735.2

XIE Jing,WANG Tianjiao,ZHANG Xvfeng,WU Jin. Research progress of the relationship between microRNA and NF-κB in the invasion and metastasis of gastric cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(4): 380-384.

References

1 Zou XN,Sun XN,Chen WQ,et al.Analysis of incidence and mortality of stomach cancer in China from 2003 to 2007[J].Tumor,2012,32(2):109-114.
2 Li Z,Zhan W,Wang Z,et al.Inhibition of PRL3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis[J].Biochem Biophys Res Commun,2006,348(1):229-237.
3 Yuan D,Li K,Zhu K,et al.Plasma miR-183 predicts recurrence and prognosis in patients with colorectal cancer[J].Cancer Biol Ther,2015,16(2):268-275.
4 Novak J,Kruzliak P,Bienertova-Vasku J,et al.MicroRNA-206:a promising theranostic marker[J].Theranostics,2014,4(2):119-133.
5 Xu F,Liu Q,Chen L,et al.Genome-wide identification of soybean microRNAs and their targets reveals their organ-specificity and responses to phosphate starvation[J].BMC Genomics,2013,31(14):66.
6 Devaraj S,Natarajan J.MiRNA-mRNA network detects hub mRNAs and cancer specific mirnas in lung cancer[J].In Silico Biol,2011,11(5/6):281-295.
7 Alshalalfa M.MicroRNA response elements-mediated miRNA-miRNA interactions in prostate cancer[J].Adv Bioinformatics,2012,2012:839837.
8 Liu F,Wu J,Ye F.Expression of miRNA-155 and miR-146a in peripheral blood mononuclear cells and plasma of oral lichen planus patients[J].Zhonghua Kou Qiang Yi Xue Za Zhi,2015,50(1):23-27.
9 Maccani MA,Marsit CJ.Exposure and fetal growth-associated miRNA alterations in the human placenta[J].Clin Epigenetics,2011,2(2):401-404.
10 Li ZR,Wang Z,Zhu BH,et al.Association of tyrosine PRL-3 phosphatase protein expression with peritoneal metastasis of gastric carcinoma and prognosis[J].Surg Today,2007,37(8):646-651.
11 Wan HY,Guo LM,Liu T,et al.Regulation of the transcription factor NF-κB1 by microRNA-9 in human gastric adenocarcinoma[J].Molecular Cancer,2010,9(16):1-10.
12 He M,Wang ZW.Current status and development of miRNA and siRNA research on gastric cancer[J].Hereditas,2011,33(9):925-930.
13 Li SC,Liao YL,Ho MR,et al.MiRNA arm selection and isomiR distribution in gastric cancer[J].BMC Genomics,2012,13(Suppl 1):13.
14 Shin JY,Kim YI,Cho SJ,et al.MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer[J].PLoS One,2014,9(1):e85205.
15 Ghosh S,Hayden MS.Celebrating 25 years of NF-kappaB research[J].Immunol Rev,2012,246(1):5-13.
16 Liu F,Xia Y,Parker AS,et al.IKK biology[J].Immunol Rev,2012,246(1):239-253.
17 Prasad S,Ravindran J,Aggarwal BB.NF-kappaB and cancer:how intimate is this relationship[J].Mol Cell Biochem,2010,336(1-2):25-37.
18 Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69-90.
19 Thu YM,Richmond A.NF-κB inducing kinase:a key regulator in the immune system and in cancer[J].Cytokine Growth Factor Rev,2010,21(4):213-226.
20 Hoesel B,Schmid JA.The complexity of NF-kappaB signaling in inflammation and cancer[J].Mol Cancer,2013,2(12):86.
21 Seo JH,Lim JW,Kim H.Differential role of ERK and p38 on NF-kappaB activation in Helicobacter pylori-infected gastric epithelial cells[J].J Cancer Prev,2013,18(4):346-350.
22 Chen Z,Liu M,Liu X,et al.COX-2 regulates E-cadherin expression through the NF-Kappa B/Snail signaling pathway in gastric cancer[J].Int J Mol Med,2013,32(1):93-100.
23 Ng MT,Van′t Hof R,Crockett JC,et al.Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9-1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease[J].Infect Immun,2010,78(3):1345-1352.
24 赵煜,曾杰.NF-κB在胃癌组织中的表达与临床病理的相关性研究[J].中国医药导报,2015,12(29):70-73.
25 Su XJ,Tang ZF,Li Q,et al.Expression and significance of rhoa and NF-kappaB in human gastric carcinoma[J].Zhonghua Zhong Liu Za Zhi,2011,33(4):276-279.
26 宋子正,臧爱民,商琰红,等.NF-κB和VEGF在胃癌中的表达及与临床病理特征相关性分析[J].陕西医学杂志,2009,38(7):876-878.
27 Jia L,Wu J,Zhang L,et al.Restoration of miR-1228 expression suppresses epithelial-mesenchymal transition in gastric cancer[J].PLoS One,2013,8(3):e58637.
28 Shin VY,Jin H,Ng EK,et al.NF-κB targets miR-16 and miR-21 in gastric cancer:involvement of prostaglandin E receptors[J].Carcinogenesis,2011,32(2):240-245.
29 Hahm KB,Lim HY,Sohn S,et al.In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis[J].Eniron Patho Toxcol Oncol,2002,21(2):165-176.
30 Park KW,Kim SJ,Oh SY.Clinicopathologic significance of nuclear factor-κB and vascular endothelial growth factor expression in advanced gastric cancer patients[J].Oncol Res Treat,2014,37(4):183-190.
31 Wan HY,Guo LM,Liu T,et al.Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma[J].Mol Cancer,2010,26(9):16-23.
32 Gao C,Zhang Z,Liu W,et al.Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer[J].Cancer,2010,116(1):41-49.
33 Xia JT,Chen LZ,Jian WH,et al.MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-κB signaling[J].J Transl Med,2014,12(2):33-39.
34 Crone SG,Jacobsen A,Federspiel B,et al.MicroRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer[J].Mol Cancer,2012,20(11):71-81.
35 Srivastava K,Srivastava A.Comprehensive review of genetic association studies and meta-analyses on miRNA polymorphisms and cancer risk[J].PLoS One,2012,7(11):e50966.

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Research progress of the relationship between microRNA and NF-κB in the invasion and metastasis of gastric cancer

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