ELAM-1在肿瘤靶向治疗中的应用进展

doi:10.11904/j.issn.1002-3070.2016.05.012

Abstract

Abstract: Endothelial leukocyte adhesion molecule-1(ELAM-1)is a member of the cell adhesion molecules,which plays a great role in the distant metastasis of tumor in ligand interactions between sLe(x)and sLe(a).Recently,it becomes a new research hotspot on applying ELAM-1 in targeted cancer therapy.Many studies Results show that by regulation of ELAM-1 in biological effects,such as ELAM-1 and ligand inhibitors,monoclonal antibody,targeting gene,and other mediates of the path of blocking therapy,thereby inhibiting or blocking tumor distant metastasis,so as to achieve the purpose of tumor therapy and improve the prognosis.Therefore,ELAM-1 is expected to exert a critical role in the tumor targeted therapy.In this paper,the application value of ELAM-1 in tumor related targeted therapy is reviewed.

Key words: ELAM-1, Tumor, Targeted therapy

CLC Number:

R730

ZUO Zhichao, SU Danke, DENG Wenjuan, JIN Guanqiao. Recent advances of ELAM-1 in targeted cancer therapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(5): 444-447.

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Recent advances of ELAM-1 in targeted cancer therapy

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