长链非编码RNA CASC2抑制肿瘤发生发展的研究概况

doi:10.11904/j.issn.1002-3070.2018.02.018

Abstract

Abstract: Long non-coding RNA(lncRNA)includes the non-coding information of most human DNA,accounting for more than 90% of the entire genome.LncRNAs consist of more than 200 nucleotides,usually lacking open reading frames and participating in the pathophysiology of the tumor.LncRNA can regulate a variety of tumor gene expression,imprinting,transcription and post-translational processing.LncRNA cancer susceptibility candidate 2(CASC2)as a potential tumor suppressor gene was first discovered in the endometrial carcinoma(EC)in 2004.CASC2 was found to be downregulated in tumors such as cervical cancer,colorectal cancer,gastric cancer,liver cancer,non-small cell lung cancer,renal cell carcinoma,bladder cancer,glioma and thyroid cancer,while CASC2 overexpression inhibited tumor cell proliferation.This shows that CASC2 has tumor suppressor effect.In other tumors such as adrenal adenocarcinoma,the transcriptional level of CASC2 remained unchanged,indicating that the tumor suppressor effect of CASC2 is tissue-specific.This review summarizes the research progress of CASC2 in tumor origin,progression,mechanisms,and clinical therapeutic effects.

Key words: Long non-coding RNA, lncRNA, CASC2, Cancer

CLC Number:

YANG Zhao, ZHAO Shiguang. Long non-coding RNA CASC2 inhibits progression and development of tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 179-183.

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Long non-coding RNA CASC2 inhibits progression and development of tumor

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