Abstract: The occurrence and development of tumor are closely related to abnormal cell metabolism.Tumor cells intake a large amount of glucose,and even with enough oxygen supply,they also generate energy primarily through the glycolysis pathway to meet the need of rapid growth.Tumor cell glycolysis is affected by many factors,and the tumor microenvironment is one of them.In recent years,there is evidence that immune/inflammatory factors such as transforming growth factor beta(TGF-β),tumor necrosis factor alpha(TNF- α),interleukin-4(IL-4),and interleukin-6(IL-6)in the microenvironment matrix play a crucial role in the process of glucose metabolism,by regulating the aerobic glycolysis of energy and material to rapidly growth and proliferation of tumor cells.Therefore,the occurrence and development of tumor are focused on coming from the point of view of regulating the glycation of tumor cells with immune/inflammatory factors in the tumor microenvironment,providing new ideas for tumor control and clinical treatment.

Key words: Tumor microenvironment, Immune/inflammatory factors, Warburg effect, Aerobic glycolysis