肿瘤相关成纤维细胞在大肠癌发生发展中的研究进展

doi:10.11904/j.issn.1002-3070.2018.03.018

Abstract

Abstract: Cancer-associated fibroblasts(CAFs)are one of the most important cellular components in the external microenvironment of tumors.CAFs can interact with tumor cells and secrete a variety of soluble factors such as growth factors,chemokines,and so on.CAFs are also involved in the proliferation,invasion,migration,metastasis and drug resistance of colorectal cancer through regulating multiple signaling pathways that play a key role in the progression of colorectal cancer.Recent studies have found that CAFs related markers and genes can be used as reference indicators for the predicting prognosis of colorectal cancer.Therefore,targeting CAFs may be a key target for early diagnosis,treatment and prognosis of colorectal cancer.This article summarizes the characteristics of CAFs,recruitment and activation process,and its role in the development of colorectal cancer in order to provide a new scientific direction for the mechanism of action and clinical application of CAFs in colorectal cancer.

Key words: Cancer-associated-fibroblasts, Tumor microenvironment, Colorectal cancer

CLC Number:

R735.3+4

LV Qiang, CHEN Hongsheng, LI Guodong, WEI Jiufeng, LIU Ming. Effects of tumor-associated fibroblasts in the development of colorectal cancer and its research progress[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 275-279.

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Effects of tumor-associated fibroblasts in the development of colorectal cancer and its research progress

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