结肠癌中肿瘤相关巨噬细胞的作用及靶向治疗的研究进展

doi:10.11904/j.issn.1002-3070.2018.05.013

Abstract

Abstract: Colon cancer is a common malignant tumor of digestive tract.The treatment and prognosis are related to many factors.Macrophage is a key regulator of tissue homeostasis and tumor microenvironment.Tumor-associated macrophage(TAM)is closely related to tumor development and poor prognosis.TAM has played a catalytic role in the occurrence,metastasis and drug resistance of colon cancer.Clinically,enhancing the therapeutic effect by strengthening the anti-tumor immune response is of great significance for remodeling the TAM and improving the therapeutic effect of tumor.

Key words: Colon cancer, Tumor-associated macrophage, Target therapy, Tumor microenvironment

CLC Number:

R735.35

LI Yue, XU Ke, HAN Zengxiang, SUN Min, FAN Guohua, ZHANG Yong. Advances in the role of tumor-associated macrophage in colon cancer and targeted therapy[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 450-454.

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Advances in the role of tumor-associated macrophage in colon cancer and targeted therapy

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