Abstract: Objective The Objective of this was to investipate study the prognostic and influence factors in patients with transanal local resection for stage T₁ rectal cancer with the distance from anal margin ≤8 cm. Methods A fotal of patients with 180 rectal cancer of stage T₁ with the distance from anal margin ≤8 cm from March 2010 to March 2014 were Retrospective analysed, and there were 90 cases received the local resection of rectal cancer as the observation group and 90 patients with the T₁ stage who underwent radical resection of rectal cancer as the control group.The postoperative recovery effects were compared between the abservation and control groups.The rates of 3-year overall survival and progression-free survival were recorded.The prognostic influence factors of rectal cancer patients at the stage T₁ with the distance from the anal margin ≤8 cm after transanal local resection were analyzed. Results The operation time, intraoperative blood loss, postoperative anal exhaust time, postoperative hospitalization stay and postoperative complications were significantly lower in the observation group than those in the control group(P＜0.05).There were no significant difference in overall survival and progression free survival between the two groups(χ²= 0.896, 0.358;P=0.344, 0.550).Logistic multivariate analysis showed that age, degree of differentiation and cutting edge properties were independent risk factors for the prognosis of patients with rectal cancer who were ≤8 cm from the anal margin(P＜0.05). Conclusion Transanal local resection for patients with rectal cancer T₁ stage from distance to anal margin can achieve similar prognostic benefits as radical surgery, and it can promote early recovery after surgery.Age, tumor differentiation and marginal properties are independent factors, which affected the prognosis of the patients undergoing surgery.

Key words: Rectal cancer, Local excision, The distance from the anal margin ≤8 cm, Prognosis