肿瘤相关巨噬细胞在三阴性乳腺癌中的表达与临床病理因素及预后关系的研究

doi:10.11904/j.issn.1002-3070.2017.01.001

Abstract

Abstract: Objective To explore the significances of expression of tumor associated macrophages(TAMs)and its correlation with microvessel density(MVD)in triple negative breast cancer(TNBC).Methods Immunohistochemistry was used to detect TAMs and MVD expression in 108 TNBC tissues and to analyze the correlation between TAMs with clinicopathological features,prognosis and MVD.Results The expression of TAMs was correlated with the tumor size,lymph node metastasis,histological grade,TNM stage and MVD,but had no statistically significant association with age.TAMs was correlated with 5 year disease free survival(DFS)and overall survival(OS);MVD was correlated with 5 year DFS,while no correlation with OS.Univariate and multivariate analyses showed that TAMs was an independent unfavorable prognostic factor for patients with TNBC.Conclusion High infiltration of TAMs indicated poor survival rate for patients with TNBC.The infiltration of TAMs was a new,important risk factor for TNBC recurrence.TAMs were closely related to MVD,by promoting tumor angiogenesis,thereby promoting TNBC growth,invasion and metastasis,and further affect the prognosis of patients with TNBC.

Key words: Triple negative breast cancer, Tumor associated macrophages, Microvessel density, Prognosis

CLC Number:

R737.9

YU Changyan, ZHEN Lina, LI Hongbing, ZHANG Yue, ZHANG Qingyuan. The correlations between expression of tumor associated macrophages and the prognostic significances in triple negative breast cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(1): 1-6.

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The correlations between expression of tumor associated macrophages and the prognostic significances in triple negative breast cancer

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