EphB6受体在恶性肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2020.01.016

Abstract

Abstract: Receptor tyrosine kinases(RTKs)are a major membrane receptor that regulates cell proliferation,differentiation and migration.Deregulation of the RTK signaling pathway can lead to many diseases,such as cancer and developmental disorders.The erythropoietin-producing hepatocellular(Eph)family is the largest subfamily of the tyrosine kinase receptor family,and its interaction with the ligand ephrin plays an important role in the development and tumorigenesis.Studies have shown a special Eph receptor lacking tyrosine kinase activity EphB6 is down-regulated in many malignancies such as breast cancer and colorectal cancer,which is a large amount of evidence that the lack of EphB6 expression is dependent on hypermethylation of its promoter DNA,resulting in promoting the progress and metastasis of tumors.EphB6 is a hot factor in recent studies.This article reviews its current research progress in malignant tumors.

Key words: EphB6, Malignant tumor, Low expression, Development and progression, Methylation

CLC Number:

BAO Le, TANG Liping. Progress of the EphB6 receptor in malignant tumors[J]. Journal of Practical Oncology, 2020, 34(1): 83-87.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.01.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I1/83

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Progress of the EphB6 receptor in malignant tumors

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