Abstract: Objective To investigate the correlation of EGFR, C-erbB-2 and VEGF expression in gastric carcinoma and normal gastric tissues and their significances to clinicopathological character.Methods one hundred and twenty cases of gastric carcinoma specimens were selected with full clinicopathological data, and another thirty cases of normal gastric mucosa specimens were selected as the control.SP immunohistochemistry was used to measure the expression of EGFR, C-erbB-2 and VEGF.The data were statistically analyzed by χ² test and kappa test.Results The positive rates of EGFR, C-erbB-2 and VEGF in gastric carcinoma(40.00%、26.70% and 52.50% respectively)were significantly higher than those in the normal tissue(7.14%、3.43% and 7.14% respectively).EGFR, C-erbB-2 and VEGF expression was not correlated with age, sex, size and degree of differentiation(P＞0.05);the positive expression rates of EGFR, C-erbB-2 and VEGF were related to depth of invasion, lymph nodes metastasis, clinical stage and distant metastasis(P＜0.05).There are significantly positive correctionship among EGFR, C-erbB-2 and VEGF expression in gastric cancer(Kappa＞0.4, P＜0.05).Conclusion The Results suggest that the high expression of EGFR, c-erbB-2 and VEGF is an useful tool for providing information about the malignant degree, prognosis, and may be as a guiding in targeted treatments for patients with gastric carcinoma.