Abstract: Objective To evaluate curative effect of locally advanced cervical cancer(LACC)treated with neoadjuvant chemotherapy and cervical locally irradiation concurrent(CCR).Methods All the cases were separated into three groups,nedaplatin and isophosphamide neoadjuvant chemotherapy(NACT),cervical locally irradiation(CLI),and CCR for evaluating curative effect.Results High effective rate evaluating by CR+PR was observed in CCR compared with NACT and CLI(88.9% vs 70.4%,63.0%),and low side effect occurred in CLI compared with NACT and CCR(25.9% vs 81.5%,85.9%).There were no difference in these three groups in lymph node metastase and infiltration of the factors.Conclusion Strong evidence suggested that CCR may be a better choice for LACC.