PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (4): 328-335.doi: 10.3969/j.issn.1002-3070.2012.04.010

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The relationship between psychosocial risk factors and colorectal cancer

LI Dandan1,HU Fulan1,ZHU Lin1,WANG Yibainai1,LIU Yupeng1,CHEN Wangyang1,CUI Binbin2,ZHAO Yashuang1   

  1. 1.Department of Epidemiology,Public Health College,Harbin Medical University,Harbin 150086;
    2.Department of Abdominal Surgery,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081
  • Received:2011-12-02 Online:2012-08-28 Published:2014-12-03

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Abstract: Objective To investigate the relationship between psychosocial risk factors and colorectal cancer.Methods A hospital based case-control study of colorectal cancer was conducted.Cases were pathologically confirmed as primary cancers of the colon and rectum.Both 256 cases and 488 controls were tested by the PSSG scale.Results Multivariate conditional logistic regression analysis showed that interpersonal disharmony(OR=32.245),children′s future(OR=3.773),changes in individual health status(OR=1.655),anxious emotion(OR=1.894)and like being alone when distressed(OR=1.928)might increase the risk of colorectal cancer;pleasing emotion(OR=0.310)and resolving problems for the environment(OR=0.194)can protect for colorectal cancer.Conclusion Psychosocial stressful factors(such as stressful life events,introversive psychological reactions and negative coping styles)are one of the important risk factors in the onset of colorectal cancer.

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