Abstract: Objective To investigate the esophagus cancer mortality trend from 1985 to 2009 and project future ten years(2010—2019)in Henan province.Methods The data of esophagus cancer deaths and population data from 1985 to 2009 was drawn from Henan Provincial Center for Tumor and Vital Statistics Database.The mortality rates of periods and the age-standardized mortality rates by Chinese population(1982)and by world Segi′s population were calculated.Joinpoint regression model was used to estimate the time trends of the mortality.Using the Leslie matrix to predict the population of Henan province during 2010—2019.The cancer mortality during 2010—2019 in Henan province was projected by APC regression model.Results A total of 72294 cases which died from esophagus cancer were reported by vital statistics and registry center in Henan province from 1985 to 2009.Among male,the age-standardized mortality rates by Chinese population was 49.49 per 100,000 during period of 1985—1989 year and decreased to 17.72 per 100,000 during period of 2005—2009 year.For female,the age-standardized rates decreased from 26.48 per 100,000 to 9.06 per 100,000.The estimated trend parameters by Joinpoint model showed that the standardized-mortality rate of esophagus cancer by Chinese standard population showed the decreasing trend in both male and female.There are two joinpoint in male and two joinpoint in female.Predicted model demonstrated that the average rate of population increased in Henan province will be 4.38 ‰ during 2010—2019.The total population of the 15 cities and counties in Henan province in 2019 will reach 14.87 million.In the future,the age-standardized mortality rates by Chinese standard population in male and female will be 17.04 per 100,000 and 8.73 per 100,000 during 2010—2014,and those in male and female are 16.67 per 100,000 and 7.98 per 100,000 respectively during 2015—2019.Conclusion The mortality rates of esophagus cancer in Henan province showed the decreasing trend during the period of 2010—2019.But the mortality rate is still high.Prevention and control measures should be continued.